Synthesis and muscarinolytic activity of quinuclidinyl benzylate iodoalkylates
Journal Article
·
· Pharmaceut. Chem. J.; (United States)
OSTI ID:6942138
Quinuclidinyl benzylate is one of the most active muscarinolytic compounds. The authors synthesized quaternary derivatives of it, containing alkyl radicals of different length at the nitrogen atom and determined their muscarinolytic activity. The length of the alkyl radical at the quaternary nitrogen atom extended from methyl to decyl. The muscarinolytic activity of iodoalkylates was determined on the longitudinal muscle of small intestines and auricles of guinea pigs.
- Research Organization:
- A.N. Nesmeyanov Institute of Organoelemental Compounds, Academy of Sciences of the USSR, Moscow
- OSTI ID:
- 6942138
- Journal Information:
- Pharmaceut. Chem. J.; (United States), Vol. 19:9
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
ALCOHOLS
BIOLOGICAL EFFECTS
GUINEA PIGS
HEART
SMALL INTESTINE
MUSCLES
BIOLOGICAL FUNCTIONS
ORGANIC IODINE COMPOUNDS
CHEMICAL COMPOSITION
CHEMICAL PREPARATION
MOLECULAR STRUCTURE
PARASYMPATHOLYTICS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
CARDIOVASCULAR SYSTEM
DIGESTIVE SYSTEM
DRUGS
FUNCTIONS
GASTROINTESTINAL TRACT
HYDROXY COMPOUNDS
INTESTINES
MAMMALS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
RODENTS
SYNTHESIS
VERTEBRATES
550600* - Medicine
ALCOHOLS
BIOLOGICAL EFFECTS
GUINEA PIGS
HEART
SMALL INTESTINE
MUSCLES
BIOLOGICAL FUNCTIONS
ORGANIC IODINE COMPOUNDS
CHEMICAL COMPOSITION
CHEMICAL PREPARATION
MOLECULAR STRUCTURE
PARASYMPATHOLYTICS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
CARDIOVASCULAR SYSTEM
DIGESTIVE SYSTEM
DRUGS
FUNCTIONS
GASTROINTESTINAL TRACT
HYDROXY COMPOUNDS
INTESTINES
MAMMALS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
RODENTS
SYNTHESIS
VERTEBRATES
550600* - Medicine