Effect of dose level and pregnancy on the distribution and toxicity of intravenous lead in rats
Female Wistar rats were injected intravenously with tracer levels of /sup 210/Pb, alone or combined with carrier Pb(NO/sub 3/)/sub 2/ at 5 or 25 mg/kg body weight at 9 or 15 days of gestation (dg). Tissue /sup 210/Pb distribution and retention, and lead excretion, were measured several times during the first 30 h and at 20 dg. Toxic effects following the administration of 25 mg/kg (a teratogenic dose) included an early decrease in hematocrit, hematuria, gastrointestinal hemorrhage, and diarrhea, as well as an eventual loss of body weight and an increase in spleen and kidney weights. The stage of pregnancy at injection did not affect the retention and distribution of lead in major organs other than the reproductive system. Following injection of the 25-mg/kg dose, deposition of lead in the liver, kidney, spleen, and lung was elevated. Disproportionately high plasma lead levels were also observed at early times after the injection of the 25-mg/kg dose, and may act as a significant factor in placental lead transfer and subsequent malformations or fetal mortality.
- Research Organization:
- Pacific Northwest Lab., Richland, WA
- DOE Contract Number:
- AC06-76RL01830
- OSTI ID:
- 6940828
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Vol. 9
- Country of Publication:
- United States
- Language:
- English
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Distribution and effects of intravenous lead in the fetoplacental unit of the rat
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59 BASIC BIOLOGICAL SCIENCES
LEAD 210
BIOLOGICAL EFFECTS
RETENTION
TISSUE DISTRIBUTION
LEAD NITRATES
BLOOD COUNT
BLOOD PLASMA
DOSE-RESPONSE RELATIONSHIPS
EXCRETION
EXPERIMENTAL DATA
GASTROINTESTINAL TRACT
INTRAVENOUS INJECTION
KIDNEYS
LEAD
LIVER
LUNGS
OVARIES
PREGNANCY
PRENATAL EXPOSURE
RATS
SPLEEN
TOXICITY
TRACER TECHNIQUES
UTERUS
WEIGHT
ALPHA DECAY RADIOISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CLEARANCE
DATA
DIGESTIVE SYSTEM
DISTRIBUTION
ELEMENTS
EVEN-EVEN NUCLEI
FEMALE GENITALS
GLANDS
GONADS
HEAVY NUCLEI
INFORMATION
INJECTION
INTAKE
ISOTOPE APPLICATIONS
ISOTOPES
LEAD COMPOUNDS
LEAD ISOTOPES
MAMMALS
MATERIALS
METALS
NITRATES
NITROGEN COMPOUNDS
NUCLEI
NUMERICAL DATA
ORGANS
OXYGEN COMPOUNDS
RADIOISOTOPES
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
551001 - Physiological Systems- Tracer Techniques
560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)