Quantitative autoradiography of neurochemicals
Several new methods have been developed that apply quantitative autoradiography to neurochemistry. These methods are derived from the 2-deoxyglucose (2DG) technique of Sokoloff (1), which uses quantitative autoradiography to measure the rate of glucose utilization in brain structures. The new methods allow the measurement of the rate of cerbral protein synthesis and the levels of particular neurotransmitter receptors by quantitative autoradiography. As with the 2DG method, the new techniques can measure molecular levels in micron-sized brain structures; and can be used in conjunction with computerized systems of image processing. It is possible that many neurochemical measurements could be made by computerized analysis of quantitative autoradiograms.
- Research Organization:
- Rockefeller Univ., New York
- OSTI ID:
- 6939285
- Journal Information:
- Life Sci.; (United States), Vol. 30:21
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
62 RADIOLOGY AND NUCLEAR MEDICINE
AUTORADIOGRAPHY
DATA PROCESSING
NEUROREGULATORS
BIOSYNTHESIS
BRAIN
CARBON 14 COMPOUNDS
GLUCOSE
IMAGE PROCESSING
PROTEINS
QUANTITATIVE CHEMICAL ANALYSIS
TRITIUM COMPOUNDS
ALDEHYDES
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
CHEMICAL ANALYSIS
DRUGS
HEXOSES
LABELLED COMPOUNDS
MONOSACCHARIDES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PROCESSING
SACCHARIDES
SYNTHESIS
400103* - Radiometric & Radiochemical Procedures- (-1987)
550601 - Medicine- Unsealed Radionuclides in Diagnostics