Toxicology - A primer on toxicology principles and applications
As the use of synthetic chemicals increased dramatically after World War II, concern about the possible adverse health and environmental effects of such use grew. The book opens with a discussion of the general principles of toxicology and how these general principles are applied in assessing the acute, subacute and chronic effects of chemicals. Both qualitative and quantitative measures of toxicity are addressed and the protocols for the various tests are described. Emphasis is placed on both the strengths and limitations of the techniques which are in current use. This is then followed by a discussion of risk assessment and risk management. Risk assessment deals with both the toxic potential of a chemical and the exposure likely to occur in specific situations. Risk management includes the steps taken to reduce or eliminate risks identified in the assessment process. The components of risk assessment are described in relation to a variety of possible toxic effects and exposure scenarios. The last part of the book provides a description and analysis of four case studies, each dealing with a different substance. These include the food additives, cyclamate and saccharin; asbestos; formaldehyde; and benzene. The basic toxicological information regarding each, and the different regulations to which they have been subject, provide the basis for exploring how the principles introduced in the first part of the book are applied in practice.
- OSTI ID:
- 6936701
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ASBESTOS
TOXICITY
BENZENE
FORMALDEHYDE
XENOBIOTICS
MAN
METABOLISM
RISK ASSESSMENT
ALDEHYDES
ANIMALS
AROMATICS
HYDROCARBONS
MAMMALS
ORGANIC COMPOUNDS
PRIMATES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology