Enhancement of tumor-initiating activity of DMBA by the carbamate fungicide mancozeb

Journal Article · Mon Jan 01 00:00:00 EST 1990 · Bulletin of Environmental Contamination and Toxicology; (USA)

DOI:https://doi.org/10.1007/BF01702359· OSTI ID:6936671

Mehrotra, N K; Kumar, S; Shukla, Y ^[1]

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1. Industrial Toxicology Research Centre, Lucknow (India)

Mancozeb is a protective fungicide and a polymeric complex of ethylene bis (dithiocarbamate) manganese with zinc salt. It is reported to be a skin irritant in rats after topical application and considered by the working group of the International Agency for Research on Cancer, Lyon, France as one of the high priority chemicals to be tested for its tumorigenic activity. Recently, mancozeb has been reported by our group to act as a tumor initiator on the mouse skin in two stage protocol of study for its carcinogenic potential. In view of these reports and its increasing demand in India as a fungicide, mancozeb (Technical grade) has been tested in the present study for its cocarcinogenic activity on the mouse skin using 7,12-dimethylbenzanthracene (DMBA) as tumor initiator and 12-0-tetradecanoyl phorbol-13-acetate (TPA) as a promoter.

• OSTI ID: 6936671
• Journal Information: Bulletin of Environmental Contamination and Toxicology; (USA), Vol. 44:1; ISSN 0007-4861
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CARBAMATES
BIOLOGICAL EFFECTS
DIMETHYLBENZANTHRACENE
ANIMAL GROWTH
CARCINOGENESIS
FUNGICIDES
MICE
NEOPLASMS
PHORBOL ESTERS
SKIN
TUMOR PROMOTERS
WEIGHT
ANIMALS
AROMATICS
BODY
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACID SALTS
CARCINOGENS
CONDENSED AROMATICS
DISEASES
ESTERS
GROWTH
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
PESTICIDES
PROMOTERS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology