Influence of caffeine on X-ray-induced killing and mutation in V79 cells

Journal Article · Sun Feb 01 00:00:00 EST 1987 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576956· OSTI ID:6936599

Bhattacharjee, S B; Bhattacharyya, N; Chatterjee, S

Effects produced by caffeine on X-irradiated Chinese hamster V79 cells depended on the growth conditions of the cells. For exponentially growing cells, nontoxic concentrations of caffeine decreased the shoulder width from the survival curve, but the slope remained unchanged. The yield of mutants under the same conditions also remained unaffected. In case of density-inhibited cells, delaying trypsinization for 24 h after X irradiation increased the survival and decreased the yield of mutants. The presence of caffeine during this incubation period inhibited such recovery and significantly increased the yield of X-ray-induced mutants.

• Research Organization: Saha Institute of Nuclear Physics, Calcutta, India
• OSTI ID: 6936599
• Journal Information: Radiat. Res.; (United States), Vol. 2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL RADIATION EFFECTS
CAFFEINE
RADIOSENSITIVITY EFFECTS
CELL KILLING
DNA REPAIR
HAMSTERS
MUTATIONS
ANALEPTICS
ANIMALS
AROMATICS
AZAARENES
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CENTRAL NERVOUS SYSTEM AGENTS
DRUGS
HETEROCYCLIC COMPOUNDS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PURINES
RADIATION EFFECTS
RECOVERY
REPAIR
RODENTS
VERTEBRATES
XANTHINES
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture