Reversible cold-induced abnormalities in myocardial perfusion and function in systemic sclerosis
Abstract
The effects of peripheral cold exposure on myocardial perfusion and function were studied in 13 patients with scleroderma without clinically evident myocardial disease. Ten patients had at least one transient, cold-induced, myocardial perfusion defect visualized by thallium-201 scintigraphy, and 12 had reversible, cold-induced, segmental left ventricular hypokinesis by two-dimensional echocardiography. The 10 patients with transient perfusion defects all had anatomically corresponding ventricular wall motion abnormalities. No one in either of two control groups (9 normal volunteers and 7 patients with chest pain and normal coronary arteriograms) had cold-induced abnormalities. This study is the first to show the simultaneous occurrence of cold-induced abnormalities in myocardial perfusion and function in patients with scleroderma. The results suggest that cold exposure in such patients may elicit transient reflex coronary vasoconstriction resulting in reversible myocardial ischemia and dysfunction. Chronic recurrent episodes of coronary spasm may lead to focal myocardial fibrosis.
- Authors:
- Publication Date:
- Research Org.:
- Johns Hopkins Medical Institutions, Baltimore, MD
- OSTI Identifier:
- 6935525
- Resource Type:
- Journal Article
- Journal Name:
- Ann. Intern. Med.; (United States)
- Additional Journal Information:
- Journal Volume: 5
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE; MYOCARDIUM; SCINTISCANNING; TEMPERATURE EFFECTS; BLOOD PRESSURE; CARDIOVASCULAR DISEASES; DIAGNOSIS; HEART; PATIENTS; PERFUSED ORGANS; THALLIUM 201; BETA DECAY RADIOISOTOPES; BODY; CARDIOVASCULAR SYSTEM; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; HEAVY NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MUSCLES; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPE SCANNING; RADIOISOTOPES; SECONDS LIVING RADIOISOTOPES; THALLIUM ISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
Citation Formats
Alexander, E L, Firestein, G S, Weiss, J L, Heuser, R R, Leitl, G, Wagner, Jr, H N, Brinker, J A, Ciuffo, A A, and Becker, L C. Reversible cold-induced abnormalities in myocardial perfusion and function in systemic sclerosis. United States: N. p., 1986.
Web. doi:10.7326/0003-4819-105-5-661.
Alexander, E L, Firestein, G S, Weiss, J L, Heuser, R R, Leitl, G, Wagner, Jr, H N, Brinker, J A, Ciuffo, A A, & Becker, L C. Reversible cold-induced abnormalities in myocardial perfusion and function in systemic sclerosis. United States. https://doi.org/10.7326/0003-4819-105-5-661
Alexander, E L, Firestein, G S, Weiss, J L, Heuser, R R, Leitl, G, Wagner, Jr, H N, Brinker, J A, Ciuffo, A A, and Becker, L C. 1986.
"Reversible cold-induced abnormalities in myocardial perfusion and function in systemic sclerosis". United States. https://doi.org/10.7326/0003-4819-105-5-661.
@article{osti_6935525,
title = {Reversible cold-induced abnormalities in myocardial perfusion and function in systemic sclerosis},
author = {Alexander, E L and Firestein, G S and Weiss, J L and Heuser, R R and Leitl, G and Wagner, Jr, H N and Brinker, J A and Ciuffo, A A and Becker, L C},
abstractNote = {The effects of peripheral cold exposure on myocardial perfusion and function were studied in 13 patients with scleroderma without clinically evident myocardial disease. Ten patients had at least one transient, cold-induced, myocardial perfusion defect visualized by thallium-201 scintigraphy, and 12 had reversible, cold-induced, segmental left ventricular hypokinesis by two-dimensional echocardiography. The 10 patients with transient perfusion defects all had anatomically corresponding ventricular wall motion abnormalities. No one in either of two control groups (9 normal volunteers and 7 patients with chest pain and normal coronary arteriograms) had cold-induced abnormalities. This study is the first to show the simultaneous occurrence of cold-induced abnormalities in myocardial perfusion and function in patients with scleroderma. The results suggest that cold exposure in such patients may elicit transient reflex coronary vasoconstriction resulting in reversible myocardial ischemia and dysfunction. Chronic recurrent episodes of coronary spasm may lead to focal myocardial fibrosis.},
doi = {10.7326/0003-4819-105-5-661},
url = {https://www.osti.gov/biblio/6935525},
journal = {Ann. Intern. Med.; (United States)},
number = ,
volume = 5,
place = {United States},
year = {Sat Nov 01 00:00:00 EST 1986},
month = {Sat Nov 01 00:00:00 EST 1986}
}