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Title: Bioconcentration potential of organic environmental chemicals in humans

Abstract

A list of environmental chemicals detectable in adipose tissue and/or milk of non-occupationally exposed humans is presented. Besides their physiochemical properties (n-octanol/water partition coefficient and water solubility), their acceptable daily intake (ADI) values, production figures, fate in the environment, concentrations in human adipose tissue, and data from total diet studies from market basket investigations are given. Average bioconcentration factors (BCF) of polychlorinated biphenyls (PCBs), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), DDT, hexachlorobenzene (HCB), dieldrin, hexachlorocyclohexane isomers (alpha-HCH, beta-HCH, gamma-HCH, delta-HCH), pentachlorophenol (PCP), and 3,5-di-tert-butyl-4-hydroxytoluene (BHT) in human adipose tissue are calculated. The bioconcentration factors (wet wt basis) of these compounds are between 3 and 47 times higher in humans than in rats. The environmental chemicals are divided into three groups in respect to their bioconcentration factors in human adipose tissue: group I, high BCF (greater than 100); group II, medium BCF (10-100); and group III, low BCF (less than 10). The bioconcentration factors are useful for hazard assessment of chemicals to humans.

Authors:
; ;
Publication Date:
Research Org.:
Gesellschaft fuer Strahlen und Umweltforschung mbH Muenchen, Germany, F.R.
OSTI Identifier:
6934673
Resource Type:
Journal Article
Journal Name:
Regul. Toxicol. Pharmacol.; (United States)
Additional Journal Information:
Journal Volume: 4
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CHLORINATED AROMATIC HYDROCARBONS; BIOLOGICAL ACCUMULATION; DDT; DIELDRIN; DIOXIN; TOLUENE; ADIPOSE TISSUE; DIET; LIVER; MAN; MILK; TISSUE DISTRIBUTION; UPTAKE; ALKYLATED AROMATICS; ANIMAL TISSUES; ANIMALS; AROMATICS; BIOLOGICAL MATERIALS; BODY; BODY FLUIDS; CONNECTIVE TISSUE; DIGESTIVE SYSTEM; DISTRIBUTION; FOOD; GLANDS; HALOGENATED AROMATIC HYDROCARBONS; HETEROCYCLIC COMPOUNDS; HYDROCARBONS; INSECTICIDES; MAMMALS; MATERIALS; ORGANIC CHLORINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; ORGANS; PESTICIDES; PRIMATES; TISSUES; VERTEBRATES; 560300* - Chemicals Metabolism & Toxicology

Citation Formats

Geyer, H, Scheunert, I, and Korte, F. Bioconcentration potential of organic environmental chemicals in humans. United States: N. p., 1986. Web. doi:10.1016/0273-2300(86)90002-4.
Geyer, H, Scheunert, I, & Korte, F. Bioconcentration potential of organic environmental chemicals in humans. United States. https://doi.org/10.1016/0273-2300(86)90002-4
Geyer, H, Scheunert, I, and Korte, F. 1986. "Bioconcentration potential of organic environmental chemicals in humans". United States. https://doi.org/10.1016/0273-2300(86)90002-4.
@article{osti_6934673,
title = {Bioconcentration potential of organic environmental chemicals in humans},
author = {Geyer, H and Scheunert, I and Korte, F},
abstractNote = {A list of environmental chemicals detectable in adipose tissue and/or milk of non-occupationally exposed humans is presented. Besides their physiochemical properties (n-octanol/water partition coefficient and water solubility), their acceptable daily intake (ADI) values, production figures, fate in the environment, concentrations in human adipose tissue, and data from total diet studies from market basket investigations are given. Average bioconcentration factors (BCF) of polychlorinated biphenyls (PCBs), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), DDT, hexachlorobenzene (HCB), dieldrin, hexachlorocyclohexane isomers (alpha-HCH, beta-HCH, gamma-HCH, delta-HCH), pentachlorophenol (PCP), and 3,5-di-tert-butyl-4-hydroxytoluene (BHT) in human adipose tissue are calculated. The bioconcentration factors (wet wt basis) of these compounds are between 3 and 47 times higher in humans than in rats. The environmental chemicals are divided into three groups in respect to their bioconcentration factors in human adipose tissue: group I, high BCF (greater than 100); group II, medium BCF (10-100); and group III, low BCF (less than 10). The bioconcentration factors are useful for hazard assessment of chemicals to humans.},
doi = {10.1016/0273-2300(86)90002-4},
url = {https://www.osti.gov/biblio/6934673}, journal = {Regul. Toxicol. Pharmacol.; (United States)},
number = ,
volume = 4,
place = {United States},
year = {Mon Dec 01 00:00:00 EST 1986},
month = {Mon Dec 01 00:00:00 EST 1986}
}