Effects of anoxia and ischemia on thallium exchange in rabbit myocardium

Conference · Sun Jan 01 00:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6932087

Krivokapich, J; Watanabe, C R; Shine, K I

The isolated, arterially perfused rabbit interventricular septum was used to study the effects of anoxia and ischemia on thallium (Tl-201) exchange. Anoxia or ischemia was introduced for periods of 20, 40, or 60 minutes during either uptake or washout of Tl-201. These interventions were followed by a reperfusion period. Effluent samples were collected during washout experiments. Anoxia lasting 20, 40, or 60 minutes during uptake resulted in a decrease in net Tl-201 uptake, which was promptly reversed upon reoxygenation. Effluent washout curves demonstrated that an increased efflux of Tl-201 occurred during 20 and 40 minutes of anoxia. Surprisingly, comparison of the Tl loss due to anoxia during uptake with the loss of Tl during washout was consistent with an increased influx of Tl-201 during the first 40 minutes of anoxia. Between 40 and 60 minutes of anoxia, the increased efflux of Tl-201 was reversed and the increase in Tl-201 influx was absent. Total ischemia for 20, 40, or 60 minutes during uptake was followed by continued accumulation of Tl-201 in 8 of 9 septa. Total ischemia during washout was followed by an immediate rapid washout of Tl-201 before a new steady-rate was achieved. The authors conclude that these results represent important differences from those reported previously using K-42. Anoxia did not increase the influx of K-42 observed with Tl-201. Also, 60 minutes of ischemia did not result in progressive loss of TL-201 as previously noted for K-42. This implies there are different sensitivities and/or mechanisms for Tl as compared to K uptake.

• Research Organization: UCLA Center for the Health Sciences, Los Angeles, CA
• OSTI ID: 6932087
• Report Number(s): CONF-840619-
• Journal Information: J. Nucl. Med.; (United States), Vol. 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ANOXIA
DIAGNOSIS
ISCHEMIA
KRYPTON ISOTOPES
DIAGNOSTIC USES
UPTAKE
MYOCARDIUM
RADIOISOTOPE SCANNING
RABBITS
THALLIUM 201
PERFUSED ORGANS
SENSITIVITY ANALYSIS
TIME DEPENDENCE
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
HEART
HEAVY NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
THALLIUM ISOTOPES
USES
VASCULAR DISEASES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics