Morphologic categorization of cell death induced by mild hyperthermia and comparison with death induced by ionizing radiation and cytotoxic drugs
This paper presents a summary of the morphological categorization of cell death, results of two in vivo studies on the cell death induced by mild hyperthermia in rat small intestine and mouse mastocytoma, and a comparison of the cell death induced by hyperthermia, radiation and cytotoxic drugs. Two distinct forms of cell death, apoptosis and necrosis, can be recognized on morphologic grounds. Apoptosis appears to be a process of active cellular self-destruction to which a biologically meaningful role can usually be attributed, whereas necrosis is a passive degenerative phenomenon that results from irreversible cellular injury. Light and transmission electron microscopic studies showed that lower body hyperthermia (43 degrees C for 30 min) induced only apoptosis of intestinal epithelial cells, and of lymphocytes, plasma cells, and eosinophils. In the mastocytoma, hyperthermia (43 degrees C for 15 min) produced widespread tumor necrosis and also enhanced apoptosis of tumor cells. Ionizing radiation and cytotoxic drugs are also known to induce apoptosis in a variety of tissues. It is attractive to speculate that DNA damage by each agent is the common event which triggers the same process of active cellular self-destruction that characteristically effects selective cell deletion in normal tissue homeostasis.
- Research Organization:
- Univ. of Queensland Medical School, Australia
- OSTI ID:
- 6927635
- Journal Information:
- Scanning Electron Microsc.; (United States), Vol. 3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
HYPERTHERMIA
BIOLOGICAL EFFECTS
TUMOR CELLS
BIOLOGICAL RADIATION EFFECTS
CELL KILLING
ANTINEOPLASTIC DRUGS
COMPARATIVE EVALUATIONS
DNA
ELECTRON MICROSCOPY
FEVER
HEAT
IN VIVO
IONIZING RADIATIONS
MICE
NECROSIS
RATS
SMALL INTESTINE
ANIMAL CELLS
ANIMALS
BODY
BODY TEMPERATURE
DIGESTIVE SYSTEM
DRUGS
ENERGY
GASTROINTESTINAL TRACT
INTESTINES
MAMMALS
MICROSCOPY
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIATIONS
RODENTS
SYMPTOMS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals