Ocular radioimmunoscintigraphy: sensitivity and practical considerations

Journal Article · Wed Jun 01 00:00:00 EDT 1988 · J. Nucl. Med.; (United States)

OSTI ID:6924233

Bomanji, J; Nimmon, C C; Hungerford, J L; Solanki, K; Granowska, M; Britton, K E

Ocular radioimmunoscintigraphy was performed in 20 patients using /sup 99m/Tc-labeled monoclonal antibody 225.28S, F(ab')2 fragments. Radioimmunoscintigraphy was positive in 13 patients and the diagnosis of ocular melanoma was confirmed by enucleation of the eye or clinical follow-up. Scintigraphy was positive in one patient with lymph node metastasis from an ocular melanoma. In six patients immunoscintigraphy was negative. Using this technique a sensitivity of 92.8% was achieved for detecting ocular melanomas. Single photon emission tomography helped to separate the lesions situated in the nasal quadrant of the eye from the adjacent nasopharyngeal activity. With appropriate imaging techniques small tumors of the order of 3 x 5 x 3 mm could be detected clearly.

• Research Organization: St. Bartholomew's Hospital, London (England)
• OSTI ID: 6924233
• Journal Information: J. Nucl. Med.; (United States), Vol. 29:6
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
EYES
MELANOMAS
RADIOIMMUNOSCINTIGRAPHY
DIAGNOSIS
SENSITIVITY ANALYSIS
ISOMERIC NUCLEI
LYMPH NODES
METASTASES
MONOCLONAL ANTIBODIES
OPHTHALMOLOGY
PATIENTS
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
TECHNETIUM 99
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BODY AREAS
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
EMISSION COMPUTED TOMOGRAPHY
FACE
HEAD
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LYMPHATIC SYSTEM
MEDICINE
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SENSE ORGANS
TECHNETIUM ISOTOPES
TOMOGRAPHY
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics