Hydroxide-catalyzed synthesis of heterocyclic aromatic amine derivatives from nitriles
Abstract
A generalized method for synthesizing a wide variety of heterocyclic aromatic amine derivatives from nitriles by use of hydroxide catalysts is presented. Nitrile dimers (3-aminocrotononitrile and dicyandiamide) and a dimer analog (anthranilonitrile) react with monomeric nitriles in the presence of hydroxide to form respectively, aminopyrimidines, diaminotriazines and aminoquinazolines.
- Authors:
- Research Org.:
- Oak Ridge Y-12 Plant, TN
- OSTI Identifier:
- 6922791
- DOE Contract Number:
- W-7405-ENG-26
- Resource Type:
- Journal Article
- Journal Name:
- J. Heterocycl. Chem.; (United States)
- Additional Journal Information:
- Journal Volume: 19
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; HETEROCYCLIC COMPOUNDS; SYNTHESIS; HYDROXIDES; CATALYTIC EFFECTS; AMINES; AROMATICS; NITRILES; HYDROGEN COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; OXYGEN COMPOUNDS; 400300* - Organic Chemistry- (-1987)
Citation Formats
Smyrl, N R, and Smithwick, III, R W. Hydroxide-catalyzed synthesis of heterocyclic aromatic amine derivatives from nitriles. United States: N. p.,
Web. doi:10.1002/jhet.5570190309.
Smyrl, N R, & Smithwick, III, R W. Hydroxide-catalyzed synthesis of heterocyclic aromatic amine derivatives from nitriles. United States. https://doi.org/10.1002/jhet.5570190309
Smyrl, N R, and Smithwick, III, R W. .
"Hydroxide-catalyzed synthesis of heterocyclic aromatic amine derivatives from nitriles". United States. https://doi.org/10.1002/jhet.5570190309.
@article{osti_6922791,
title = {Hydroxide-catalyzed synthesis of heterocyclic aromatic amine derivatives from nitriles},
author = {Smyrl, N R and Smithwick, III, R W},
abstractNote = {A generalized method for synthesizing a wide variety of heterocyclic aromatic amine derivatives from nitriles by use of hydroxide catalysts is presented. Nitrile dimers (3-aminocrotononitrile and dicyandiamide) and a dimer analog (anthranilonitrile) react with monomeric nitriles in the presence of hydroxide to form respectively, aminopyrimidines, diaminotriazines and aminoquinazolines.},
doi = {10.1002/jhet.5570190309},
url = {https://www.osti.gov/biblio/6922791},
journal = {J. Heterocycl. Chem.; (United States)},
number = ,
volume = 19,
place = {United States},
year = {},
month = {}
}
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