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Title: Thyroid function after mantle irradiation in Hodgkin's disease

Abstract

The thyroid function of 64 patients with Hodgkin's disease who received mantle irradiation during the period 1966 to 1976 was studied. More than two-thirds (44 to 64) had some thyroid dysfunction. Twenty had mild dysfunction manifested by an abnormal thyroid-stimulating hormone response to thyrotropin-releasing hormone. Twenty had what could be termed compensated hypothyroidism while four were overtly hypothyroid. The severity of dysfunction was not related to age, sex, or chemotherapy. We found, however, that decreased thyroid function was inversely proportional to the length of time between a diagnostic lymphangiogram and the radiation therapy. These results are consistent with the hypothesis that the iodine load of the lymphangiogram renders the thyroid gland more radiosensitive. Thyroxine suppression of the thyroid gland during the period from the lymphangiogram through the termination of radiation therapy is suggested as a means of avoiding thyroid injury.

Authors:
; ; ; ; ;
Publication Date:
Research Org.:
Dartmouth-Hitchcock Medical Center, Hanover, NH
OSTI Identifier:
6921632
Resource Type:
Journal Article
Journal Name:
J. Am. Med. Assoc.; (United States)
Additional Journal Information:
Journal Volume: 245:1
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; HODGKINS DISEASE; RADIOTHERAPY; THYROID; CHEMOTHERAPY; HYPOTHYROIDISM; PATIENTS; RADIOSENSITIVITY; THYROXINE; TRH; AMINO ACIDS; BODY; CARBOXYLIC ACIDS; DISEASES; ENDOCRINE DISEASES; ENDOCRINE GLANDS; GLANDS; HORMONES; LYMPHOMAS; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; ORGANS; PEPTIDE HORMONES; RADIOLOGY; THERAPY; THYROID HORMONES; 550600* - Medicine; 550603 - Medicine- External Radiation in Therapy- (1980-); 550900 - Pathology

Citation Formats

Smith, Jr, R E, Adler, R A, Clark, P, Brinck-Johnsen, T, Tulloh, M E, and Colten, T. Thyroid function after mantle irradiation in Hodgkin's disease. United States: N. p., 1981. Web. doi:10.1001/jama.1981.03310260024022.
Smith, Jr, R E, Adler, R A, Clark, P, Brinck-Johnsen, T, Tulloh, M E, & Colten, T. Thyroid function after mantle irradiation in Hodgkin's disease. United States. https://doi.org/10.1001/jama.1981.03310260024022
Smith, Jr, R E, Adler, R A, Clark, P, Brinck-Johnsen, T, Tulloh, M E, and Colten, T. 1981. "Thyroid function after mantle irradiation in Hodgkin's disease". United States. https://doi.org/10.1001/jama.1981.03310260024022.
@article{osti_6921632,
title = {Thyroid function after mantle irradiation in Hodgkin's disease},
author = {Smith, Jr, R E and Adler, R A and Clark, P and Brinck-Johnsen, T and Tulloh, M E and Colten, T},
abstractNote = {The thyroid function of 64 patients with Hodgkin's disease who received mantle irradiation during the period 1966 to 1976 was studied. More than two-thirds (44 to 64) had some thyroid dysfunction. Twenty had mild dysfunction manifested by an abnormal thyroid-stimulating hormone response to thyrotropin-releasing hormone. Twenty had what could be termed compensated hypothyroidism while four were overtly hypothyroid. The severity of dysfunction was not related to age, sex, or chemotherapy. We found, however, that decreased thyroid function was inversely proportional to the length of time between a diagnostic lymphangiogram and the radiation therapy. These results are consistent with the hypothesis that the iodine load of the lymphangiogram renders the thyroid gland more radiosensitive. Thyroxine suppression of the thyroid gland during the period from the lymphangiogram through the termination of radiation therapy is suggested as a means of avoiding thyroid injury.},
doi = {10.1001/jama.1981.03310260024022},
url = {https://www.osti.gov/biblio/6921632}, journal = {J. Am. Med. Assoc.; (United States)},
number = ,
volume = 245:1,
place = {United States},
year = {Fri Jan 02 00:00:00 EST 1981},
month = {Fri Jan 02 00:00:00 EST 1981}
}