Treatment-related toxicities with Fluosol-DA 20% infusion during radiation in advanced head and neck malignancies

Journal Article · Thu Mar 01 00:00:00 EST 1990 · Laryngoscope; (USA)

DOI:https://doi.org/10.1288/00005537-199003000-00005· OSTI ID:6919701

Campbell, B H; Janjan, N A; Byhardt, R W; Toohill, R J ^[1]

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1. Medical College of Wisconsin, Milwaukee (USA)

Fluosol-DA 20%, a synthetic perfluorocarbon emulsion first developed as a blood substitute, is currently being investigated as a radiation sensitizer. Theoretically, an oxygen-carrying perfluorocarbon emulsion combined with oxygen inhalation might be able to increase tumor response by decreasing the relative proportion of hypoxic tumor cells. Twenty-one patients with advanced head and neck malignancies receiving primary radiation therapy were evaluated for treatment-related toxicity. Mucosal reactions and weight loss during treatment in the group of patients who received the perfluorocarbon emulsion and the group who did not were comparable. Late sequelae appeared comparable. No patient in either group who completed radiation therapy required an interruption of the treatment course. We conclude that Fluosol-DA 20% is a tolerated adjunct to primary radiation therapy. Further study is needed to determine whether the agent will improve local/regional tumor control.

• OSTI ID: 6919701
• Journal Information: Laryngoscope; (USA), Vol. 100:3; ISSN 0023-852X
• Country of Publication: United States
• Language: English

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