Local cerebral blood flow and partition coefficients measured in cerebral astrocytomas of different grades of malignancy

Journal Article · Wed Feb 01 00:00:00 EST 1984 · Surg. Neurol. (Tryon, N.C.); (United States)

DOI:https://doi.org/10.1016/0090-3019(84)90329-X· OSTI ID:6916286

Tachibana, H; Meyer, J S; Rose, J E; Kandula, P

Local cerebral blood flow and local partition coefficients were measured in patients with different grades of malignant cerebral astrocytomas (n . 5) who inhaled 35% stable xenon during computed tomography scanning. Results were compared with those in age-matched normal subjects (n . 5. Mean values for local cerebral blood flow in the gray matter in patients with astrocytomas were decreased throughout the tumor mass and surrounding brain that was apparently free of tumor. Patients with highly malignant glioblastoma multiforme (astrocytoma grade IV; n . 2) showed more variable values for local cerebral blood flow and local partition coefficients compared to those with astrocytomas of lower grades (grades I-II; n . 3). Local partition coefficients in gray matter invaded by grade IV astrocytoma were significantly higher than those in gray matter invaded by grade I-III astrocytomas. Local cerebral blood flow and local partition coefficients in the brain tissue surrounding grade IV astrocytomas were reduced to a greater extent than those in more benign tumors.

• Research Organization: Veterans Administration Hospital, Houston, Texas
• OSTI ID: 6916286
• Journal Information: Surg. Neurol. (Tryon, N.C.); (United States), Vol. 21:2
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CEREBRUM
BLOOD FLOW
COMPUTERIZED TOMOGRAPHY
BRAIN
NEOPLASMS
PATHOGENESIS
XENON ISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
DIAGNOSTIC TECHNIQUES
DISEASES
ISOTOPES
NERVOUS SYSTEM
ORGANS
TOMOGRAPHY
550601* - Medicine- Unsealed Radionuclides in Diagnostics