Clinical laboratory manifestations of exposure to dioxin in children. A six-year study of the effects of an environmental disaster near Seveso, Italy

Journal Article · Fri Nov 21 00:00:00 EST 1986 · JAMA, J. Am. Med. Assoc.; (United States)

DOI:https://doi.org/10.1001/jama.1986.03380190057025· OSTI ID:6914227

Mocarelli, P; Marocchi, A; Brambilla, P; Gerthoux, P; Young, D S; Mantel, N

Following a major environmental accident near Seveso, Italy, on July 10, 1976, we attempted to determine if the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) released into the atmosphere had any effect on the liver function and lipid metabolism of exposed children. From July 1976 to June 1982, we analyzed the results of more than 4500 laboratory tests (alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase, alkaline phosphatase, cholesterol, and triglycerides in plasma and delta-aminolevulinic acid in urine) in a population of about 1500 children aged 6 to 10 years at the moment of the accident. The children exposed to the highest concentration of TCDD showed alterations in serum gamma-glutamyltransferase and alanine aminotransferase activity compared with the control group. These differences were restricted to values inside limits set from the lower end of the normal range to slightly above it. The observed abnormalities were slight and disappeared with time.

• Research Organization: Dept. of Clinical Pathology, Milan, Italy
• OSTI ID: 6914227
• Journal Information: JAMA, J. Am. Med. Assoc.; (United States), Vol. 19
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DIOXIN
ENVIRONMENTAL EXPOSURE
HEALTH HAZARDS
ACCIDENTS
BLOOD CHEMISTRY
CHILDREN
ENZYME ACTIVITY
ITALY
LIPIDS
LIVER
MEDICAL SURVEILLANCE
METABOLISM
PHOSPHOTRANSFERASES
URINE
AGE GROUPS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
DIGESTIVE SYSTEM
ENZYMES
EUROPE
GLANDS
HAZARDS
HETEROCYCLIC COMPOUNDS
MATERIALS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PHOSPHORUS-GROUP TRANSFERASES
SURVEILLANCE
TRANSFERASES
WASTES
WESTERN EUROPE
560300* - Chemicals Metabolism & Toxicology