Identification of heptanal and nonanal in bronchoalveolar lavage from rats exposed to low levels of ozone

Journal Article · Thu Oct 15 00:00:00 EDT 1992 · Biochemical and Biophysical Research Communications; (United States)

DOI:https://doi.org/10.1016/0006-291X(92)92359-6· OSTI ID:6913075

Cueto, R; Squadrito, G L; Bermudez, E; Pryor, W A ^[1]

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1. Biodynamics Institute, Louisiana State University, Baton Rouge (United States)

Heptanal and nonanal are identified from in vitro studies as potential biomarkers of exposure to ozone, the former resulting from ozonation of palmitoleic acid and the latter from oleic acid. An analytical method is developed based on derivatization using O-pentafluorobenzylhydroxylamine HCl and gas chromatography. These molecules also are present in the lung lavage of Sprague-Dawley rats exposed to 1.3 ppm ozone for 10 hr. These results suggest aldehydes may be useful dosimeters for ozone and indicate that unsaturated fatty acids in the lung lining fluid layer undergo ozonation in vivo.

• OSTI ID: 6913075
• Journal Information: Biochemical and Biophysical Research Communications; (United States), Vol. 188:1; ISSN 0006-291X
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LUNGS
SENSITIVITY
OZONE
TOXICITY
ALDEHYDES
BIOLOGICAL MARKERS
GAS CHROMATOGRAPHY
LAVAGE
RATS
ANIMALS
BODY
CHROMATOGRAPHY
MAMMALS
ORGANIC COMPOUNDS
ORGANS
RESPIRATORY SYSTEM
RODENTS
SEPARATION PROCESSES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology