Influence of digestive processes on the absorption and fate of quinoline ingested by rainbow trout (Oncorhynchus mykiss)
- Pacific Northwest Lab., Richland, WA (United States)
- Oregon State Univ., Corvallis, OR (United States). Dept. of Fisheries and Wildlife
Rainbow trout were fed pelleted food containing [[sup 14]C]-quinoline to access the relationship of digestive processes to xenobiotic pharmacokinetics. The pH of material in the stomach of rainbow trout ranged from 2.7 to 5.2 and was highly correlated (r = 0.89) with the size of the food bolus remaining. At 2 h after feeding, 67% of the quinoline was estimated to be un-ionized in the alkaline environment of the intestine; however, relative concentrations in the intestine were about 8% of those measured in the stomach. Gastric absorption was consistent with known serum profiles and excretion patterns of dietary quinoline. Rates of gallbladder emptying appeared to exceed rates of hepatic bile secretion until about 8 h after a single feeding. Time since feeding influenced both the amount and concentration of quinoline-derived radioactivity in the bile. Consecutive feedings enhanced the movement of the food bolus and associated radioactivity from the upper and midgut regions, but had no effect on disposition of quinoline.
- DOE Contract Number:
- AC06-76RL01830
- OSTI ID:
- 6910228
- Journal Information:
- Environmental Toxicology and Chemistry; (United States), Vol. 9; ISSN 0730-7268
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
QUINOLINES
INTESTINAL ABSORPTION
METABOLISM
TROUT
SENSITIVITY
CARBON 14 COMPOUNDS
TRACER TECHNIQUES
ABSORPTION
ANIMALS
AQUATIC ORGANISMS
AROMATICS
AZAARENES
AZINES
CARBON COMPOUNDS
FISHES
HETEROCYCLIC COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIDINES
SORPTION
UPTAKE
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology