Cerebral correlates of depressed behavior in rats, visualized using /sup 14/C-2-deoxyglucose autoradiography
/sup 14/C-2-Deoxyglucose (2DG) was used to investigate changes in the rate of cerebral metabolism in 3 rat models of depressed behavior. The models had already been established in the literature and were induced by injections of alpha-methyl-para-tyrosine, withdrawal from chronic amphetamine, or stress. We verified that exploratory behaviors were depressed in each model and that an antidepressant drug, tranylcypromine, prevented the depressed behavior in each model. 2DG studies revealed that the rate of regional glucose metabolism was elevated bilaterally in the lateral habenula of each of the 3 models. Regional metabolic rates were reduced in each model in the dorsal medial prefrontal cortex, anterior ventral nucleus of the thalamus, and inferior colliculus. Forebrain global metabolic rates were also reduced in each of the models. Tranylcypromine prevented the elevated rate of lateral habenula metabolism seen in each of the models alone but did not significantly affect the rates of global metabolism. Our findings of identical metabolic changes in each of the models indicate that these changes are not idiosyncratic to a particular model; rather, they correlate with a generalizable state of depressed exploratory behavior in rats.
- Research Organization:
- Univ. of California, Los Angeles (USA)
- OSTI ID:
- 6908729
- Journal Information:
- J. Neurosci.; (United States), Vol. 8:6
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
GLUCOSE
METABOLISM
NERVOUS SYSTEM DISEASES
PATHOGENESIS
RATS
BEHAVIOR
ANTIDEPRESSANTS
AUTORADIOGRAPHY
BIOLOGICAL MODELS
BRAIN
CARBON COMPOUNDS
CELL NUCLEI
ALDEHYDES
ANIMALS
BODY
CARBOHYDRATES
CELL CONSTITUENTS
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
DISEASES
DRUGS
HEXOSES
MAMMALS
MONOSACCHARIDES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PSYCHOTROPIC DRUGS
RODENTS
SACCHARIDES
VERTEBRATES
550501* - Metabolism- Tracer Techniques
550901 - Pathology- Tracer Techniques