Posthemorrhage glycogen and lactate metabolism in the liver: an experimental study with postprandial rats
Glycogen and lactate metabolism was studied in livers from three groups of postprandial rats sustaining 70 mm Hg hemorrhagic hypotension for variable periods, 60 min (60H group), 120 min (120H group), and nonbled controls. The donor livers were investigated after completed hemorrhage using an in vitro perfusion system with L-lactate as substrate, together with U-/sup 14/C-lactate. The residual glycogen stores were determined after perfusions. The incorporation of labelled lactate to glucose was increased in the 120H group by 66.7% and 116.8% compared to the 60H group and controls (p less than 0.01), but glycogenolysis was still the main source of glucose released in the 120H group. Glycogen formation from labelled lactate was 46.6% higher in the 120H group compared to controls (p less than 0.05) and lactate oxidation was decreased by 67.5% (p less than 0.05). The data suggest that hepatocytes are capable of rapid change from glycolysis to gluconeogenesis during hemorrhagic hypovolemia. However, energy-sparing glycogen breakdown is given priority over gluconeogenesis as long as glycogen remains available.
- Research Organization:
- Karolinska Hospital, Stockholm (Sweden)
- OSTI ID:
- 6908728
- Journal Information:
- J. Trauma; (United States), Vol. 28:6
- Country of Publication:
- United States
- Language:
- English
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GLYCOGEN
METABOLISM
LACTATES
CARBON 14 COMPOUNDS
HEMORRHAGE
LIVER
PERFUSED ORGANS
RATS
TRACER TECHNIQUES
ANIMALS
BODY
CARBOHYDRATES
CARBOXYLIC ACID SALTS
DIGESTIVE SYSTEM
GLANDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
POLYSACCHARIDES
RODENTS
SACCHARIDES
SYMPTOMS
VERTEBRATES
550501* - Metabolism- Tracer Techniques