Chronic cadmium exposure during pregnancy in the mouse: influence of exposure levels on fetal and maternal uptake

Journal Article · Fri Jan 01 00:00:00 EST 1988 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398809531152· OSTI ID:6908078

Webster, W S

The uptake and distribution of orally administered cadmium-109 was studied in pregnant mice. Female outbred QS mice were given cadmium (Cd) supplemented drinking water for 1 mo before pregnancy and for the duration of pregnancy. The water contained either 0.0015 ppm Cd, 0.24 ppm Cd, or 40 ppm Cd. For the duration of pregnancy, 1.48 micrograms Cd/l (0.0015 ppm) in each solution was in the form of /sup 109/Cd (1 mCi/l). Control mice were given distilled/deionized water. On the day before term the mice were killed and a variety of adult and fetal tissues were examined in a gamma counter to determine their /sup 109/Cd concentrations. For each group the /sup 109/Cd concentration was highest in the maternal gastrointestinal tract, liver, and kidneys and lowest in the central nervous system (CNS) and blood. In general, the /sup 109/Cd concentrations in each organ were similar for each group of mice and were therefore independent of the overall oral Cd dose. A notable exception was the lower level in the duodenum in the 40 ppm group. In the fetal unit the chorioallantoic placenta contained the highest concentration of /sup 109/Cd. Concentrations in the fetuses were very low, comparable to those in the adult CNS. The /sup 109/Cd levels in the fetuses from group A were about fivefold greater than those of the fetuses from group C. There was no statistically significant evidence of specific localization in the fetal brain, kidney, or liver.

• Research Organization: Univ. of Sydney, New South Wales (Australia)
• OSTI ID: 6908078
• Journal Information: J. Toxicol. Environ. Health; (United States), Vol. 24:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
CADMIUM
TISSUE DISTRIBUTION
CADMIUM 109
CHRONIC EXPOSURE
FETUSES
METABOLISM
MICE
ORAL ADMINISTRATION
PLACENTA
PREGNANCY
TRACER TECHNIQUES
UPTAKE
ANIMALS
BETA DECAY RADIOISOTOPES
CADMIUM ISOTOPES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
FETAL MEMBRANES
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MEMBRANES
METALS
NUCLEI
RADIOISOTOPES
RODENTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
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