Binding (of /sup 3/H-spiperone) in the mouse brain after intraperitoneal injection

Journal Article · Thu Aug 01 00:00:00 EDT 1985 · Bull. Exp. Biol. Med. (Engl. Transl.); (United States)

DOI:https://doi.org/10.1007/BF00799074· OSTI ID:6906766

Zharkovskii, A M; Chereshka, K S; Zharkovskaya, T A

In this investigation, the binding of/sup 3/H-spiperone was studied after intraperitoneal injection into mice. The results of these experiments show that after intraperitoneal injection /sup 3/H-spiperone binds specifically with receptors of the cortex and basal ganglia of the mouse brain. Neuroleptics with varied chemical structure displace /sup 3/H-spiperone from its binding sites. Although after intraperitoneal injection the level of specific binding is rather lower than after intravenous injection, the authors maintain that the relative simplicity, reproducibility, and economy of the method make it more acceptable.

• Research Organization: Tarto Univ.,
• OSTI ID: 6906766
• Journal Information: Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Vol. 99:3
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
NERVE CELLS
BINDING ENERGY
PSYCHOTROPIC DRUGS
RADIORECEPTOR ASSAY
TRANQUILIZERS
BRAIN
CELL MEMBRANES
DOPAMINE
INTRAPERITONEAL INJECTION
INTRAVENOUS INJECTION
LIGANDS
MICE
RECEPTORS
RETENTION
TISSUE DISTRIBUTION
TRITIUM COMPOUNDS
AMINES
ANIMAL CELLS
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CELL CONSTITUENTS
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
DISTRIBUTION
DRUGS
ENERGY
HYDROXY COMPOUNDS
INJECTION
INTAKE
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
MEMBRANES
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
PROTEINS
RODENTS
SOMATIC CELLS
SYMPATHOMIMETICS
TRACER TECHNIQUES
VERTEBRATES
550501* - Metabolism- Tracer Techniques