Chloracne associated with employment in the production of pentachlorophenol
- National Institute for Occupational Safety and Health, Cincinnati, OH (USA)
To evaluate the association between exposure to pentachlorophenol (PCP) and the occurrence of chloracne, we studied the medical and personnel records for individuals employed in the manufacturing of PCP. Forty-seven cases of chloracne were identified among 648 workers (7.0%) assigned to PCP production at a single plant between 1953 and 1978. The annual incidence rate varied considerably, ranging from 0 (in 1953) to 1.46 (in 1978). No linear trend in the risk of chloracne was observed with the duration of employment in the pentachlorophenol department. Workers with a documented episode of direct skin contact with PCP had a significantly increased risk of chloracne compared with workers who did not have a documented episode of direct skin contact (cumulative incidence ratio = 4.6; 95% confidence interval 2.6-8.1). Our results confirm that chloracne is associated with exposure to PCP contaminated with hexachlorinated, heptachlorinated, and octachlorinated dibenzo-p-dioxins and dibenzofurans.
- OSTI ID:
- 6905316
- Journal Information:
- American Journal of Industrial Medicine; (USA), Vol. 17:4; ISSN 0271-3586
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CHLORINATED AROMATIC HYDROCARBONS
HEALTH HAZARDS
DERMATITIS
EPIDEMIOLOGY
CHEMICAL INDUSTRY
ILLINOIS
OCCUPATIONAL DISEASES
OCCUPATIONAL EXPOSURE
PERSONNEL
RISK ASSESSMENT
AROMATICS
DISEASES
FEDERAL REGION V
HALOGENATED AROMATIC HYDROCARBONS
HAZARDS
INDUSTRY
NORTH AMERICA
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
SKIN DISEASES
USA
560300* - Chemicals Metabolism & Toxicology