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Title: Stage IV-S neuroblastoma. Results with definitive therapy

Abstract

The results of management of 14 patients with Stage IV-S neuroblastoma are reported. The treatment policy, although not consistent over this time span, in general used a combination of radiotherapy and chemotherapy or infrequently one modality alone. Twelve of 14 (86%) survived more than 6 years. One patient, with a solitary mediastinal primary tumor, died of rapidly progressive disease at three months. The other death occurred in a 4.5-year-old presenting with hepatomegaly at diagnosis followed by skeletal dissemination 2.5 years later. Thirteen of the patients were younger than 1 year of age. Of the 11 patients that received radiotherapy, 4 experienced mild asymptomatic scoliosis or kyphoscoliosis at 3 to 12 years after initial therapy. A review of the literature indicates that spontaneous regression in this tumor is very frequent; therefore, it is recommended that for the common presentation of massive hepatomegaly in an infant, close observation is warranted, unless life threatening complications occur. However, initial therapeutic intervention may be indicated in those patients with life threatening presentations. This data did not substantiate the necessity for complete surgical excision of the primary tumor, as has been suggested by others.

Authors:
; ; ;
Publication Date:
Research Org.:
Mallinckrodt Institute of Radiology, St. Louis, Missouri
OSTI Identifier:
6905113
Resource Type:
Journal Article
Journal Name:
Cancer (Philadelphia); (United States)
Additional Journal Information:
Journal Volume: 53:10
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; NEOPLASMS; RADIOTHERAPY; SIDE EFFECTS; AGE DEPENDENCE; CHEMOTHERAPY; PATIENTS; SURVIVAL TIME; DISEASES; MEDICINE; NUCLEAR MEDICINE; RADIOLOGY; THERAPY; 560151* - Radiation Effects on Animals- Man; 550603 - Medicine- External Radiation in Therapy- (1980-)

Citation Formats

Stokes, S H, Thomas, P R, Perez, C A, and Vietti, T J. Stage IV-S neuroblastoma. Results with definitive therapy. United States: N. p., 1984. Web. doi:10.1002/1097-0142(19840515)53:10<2083::AID-CNCR2820531014>3.0.CO;2-S.
Stokes, S H, Thomas, P R, Perez, C A, & Vietti, T J. Stage IV-S neuroblastoma. Results with definitive therapy. United States. https://doi.org/10.1002/1097-0142(19840515)53:10<2083::AID-CNCR2820531014>3.0.CO;2-S
Stokes, S H, Thomas, P R, Perez, C A, and Vietti, T J. 1984. "Stage IV-S neuroblastoma. Results with definitive therapy". United States. https://doi.org/10.1002/1097-0142(19840515)53:10<2083::AID-CNCR2820531014>3.0.CO;2-S.
@article{osti_6905113,
title = {Stage IV-S neuroblastoma. Results with definitive therapy},
author = {Stokes, S H and Thomas, P R and Perez, C A and Vietti, T J},
abstractNote = {The results of management of 14 patients with Stage IV-S neuroblastoma are reported. The treatment policy, although not consistent over this time span, in general used a combination of radiotherapy and chemotherapy or infrequently one modality alone. Twelve of 14 (86%) survived more than 6 years. One patient, with a solitary mediastinal primary tumor, died of rapidly progressive disease at three months. The other death occurred in a 4.5-year-old presenting with hepatomegaly at diagnosis followed by skeletal dissemination 2.5 years later. Thirteen of the patients were younger than 1 year of age. Of the 11 patients that received radiotherapy, 4 experienced mild asymptomatic scoliosis or kyphoscoliosis at 3 to 12 years after initial therapy. A review of the literature indicates that spontaneous regression in this tumor is very frequent; therefore, it is recommended that for the common presentation of massive hepatomegaly in an infant, close observation is warranted, unless life threatening complications occur. However, initial therapeutic intervention may be indicated in those patients with life threatening presentations. This data did not substantiate the necessity for complete surgical excision of the primary tumor, as has been suggested by others.},
doi = {10.1002/1097-0142(19840515)53:10<2083::AID-CNCR2820531014>3.0.CO;2-S},
url = {https://www.osti.gov/biblio/6905113}, journal = {Cancer (Philadelphia); (United States)},
number = ,
volume = 53:10,
place = {United States},
year = {Tue May 15 00:00:00 EDT 1984},
month = {Tue May 15 00:00:00 EDT 1984}
}