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Title: Thymus and pulmonary lymph node response to acute and subchronic ozone inhalation in the mouse

Abstract

Ozone is an oxidant gas which primarily injures the centroacinar portion of the lung. While the classical lesion of oxidant-mediated lung damage is relatively well described, the effect of this form of injury on the lymphocytic arm of the pulmonary defense system is less clear. In the present experiments Cd-1 female mice were exposed to ozone at a level of 0.7 ppm for 20 hr per day for 1-28 days and the lymphocyte response was observed in the pulmonary lymph nodes and the thymus. In the mediastinal lymph nodes a marked hyperplastic response was observed that was prominent in the paracortex and was characterized by the presence of blastic forms. In contrast, the thymus underwent an atrophic response characterized by cellular loss in the cortical region. Prior surgical adrenalectomy of ozone-exposed animals eliminated part, but not all of the thymic atrophy response, indicating that adrenal-mediated stress alone did not account for all the observed effect. Thymectomy of animals prior to ozone exposure produced a 40% reduction in the mediastinal lymph node response, suggesting that a part of the node hyperplasia is thymus dependent. The results of these experiments indicate that lymphoid organs are altered following oxidant-mediated lung damage in themore » mouse. The changes are observed in the absence of exogenous antigenic stimulation and suggest that lymphoid cells are in integral aspect of the host response to high-level ozone inhalation.« less

Authors:
;
Publication Date:
Research Org.:
General Motors Research Labs., Warren, MI
OSTI Identifier:
6904690
Resource Type:
Journal Article
Journal Name:
Environ. Res.; (United States)
Additional Journal Information:
Journal Volume: 38:2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; LYMPH NODES; CELL PROLIFERATION; LYMPHOCYTES; INJURIES; OZONE; TOXICITY; THYMUS; ATROPHY; INHALATION; MICE; ANIMAL CELLS; ANIMALS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CONNECTIVE TISSUE CELLS; INTAKE; LEUKOCYTES; LYMPHATIC SYSTEM; MAMMALS; MATERIALS; ORGANS; PATHOLOGICAL CHANGES; RODENTS; SOMATIC CELLS; VERTEBRATES; 560300* - Chemicals Metabolism & Toxicology

Citation Formats

Dziedzic, D, and White, H J. Thymus and pulmonary lymph node response to acute and subchronic ozone inhalation in the mouse. United States: N. p., 1985. Web.
Dziedzic, D, & White, H J. Thymus and pulmonary lymph node response to acute and subchronic ozone inhalation in the mouse. United States.
Dziedzic, D, and White, H J. 1985. "Thymus and pulmonary lymph node response to acute and subchronic ozone inhalation in the mouse". United States.
@article{osti_6904690,
title = {Thymus and pulmonary lymph node response to acute and subchronic ozone inhalation in the mouse},
author = {Dziedzic, D and White, H J},
abstractNote = {Ozone is an oxidant gas which primarily injures the centroacinar portion of the lung. While the classical lesion of oxidant-mediated lung damage is relatively well described, the effect of this form of injury on the lymphocytic arm of the pulmonary defense system is less clear. In the present experiments Cd-1 female mice were exposed to ozone at a level of 0.7 ppm for 20 hr per day for 1-28 days and the lymphocyte response was observed in the pulmonary lymph nodes and the thymus. In the mediastinal lymph nodes a marked hyperplastic response was observed that was prominent in the paracortex and was characterized by the presence of blastic forms. In contrast, the thymus underwent an atrophic response characterized by cellular loss in the cortical region. Prior surgical adrenalectomy of ozone-exposed animals eliminated part, but not all of the thymic atrophy response, indicating that adrenal-mediated stress alone did not account for all the observed effect. Thymectomy of animals prior to ozone exposure produced a 40% reduction in the mediastinal lymph node response, suggesting that a part of the node hyperplasia is thymus dependent. The results of these experiments indicate that lymphoid organs are altered following oxidant-mediated lung damage in the mouse. The changes are observed in the absence of exogenous antigenic stimulation and suggest that lymphoid cells are in integral aspect of the host response to high-level ozone inhalation.},
doi = {},
url = {https://www.osti.gov/biblio/6904690}, journal = {Environ. Res.; (United States)},
number = ,
volume = 38:2,
place = {United States},
year = {Sun Dec 01 00:00:00 EST 1985},
month = {Sun Dec 01 00:00:00 EST 1985}
}