Remarkable elevation of leukotriene B4 in rat skin after induction of UV photodermatitis

Journal Article · Sun Apr 01 00:00:00 EST 1990 · Inflammation (New York); (USA)

DOI:https://doi.org/10.1007/BF00917458· OSTI ID:6897083

Nakaguma, H; Takahashi, H ^[1]

---

1. Kumamoto Univ. Medical School (Japan)

Leukotriene B4 in the skin was remarkably elevated in the rat, but not in the guinea pig or the mouse 48 h after UV-B irradiation. These results were consistent with interspecies difference of PMN infiltration caused by UV-B irradiation. LTB4 in the rat skin was determined by both high-performance liquid chromatography and radioimmunoassay. LTB4 in the rat skin started to increase 24 h after irradiation and became about 65-fold higher in the irradiated site than in the nonirradiated site at the end of 48 h. This elevation was strongly inhibited by topical application of two 5-lipoxygenase inhibitors, AA-861 and piriprost, although the inflammatory reaction or infiltration of polymorphonuclear leukocytes was not much improved.

• OSTI ID: 6897083
• Journal Information: Inflammation (New York); (USA), Vol. 14:2; ISSN 0360-3997
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
PROSTAGLANDINS
RADIOIMMUNOASSAY
COMPARATIVE EVALUATIONS
ENZYME INHIBITORS
GENETIC VARIABILITY
GUINEA PIGS
LEUKOCYTES
LIQUID COLUMN CHROMATOGRAPHY
MICE
OXYGENASES
RADIODERMATITIS
RATS
SKIN
ULTRAVIOLET RADIATION
ANIMALS
BIOASSAY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL VARIABILITY
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CHROMATOGRAPHY
DERMATITIS
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTROMAGNETIC RADIATION
ENZYMES
IMMUNOASSAY
IMMUNOLOGY
INJURIES
ISOTOPE APPLICATIONS
LOCAL RADIATION EFFECTS
MAMMALS
MATERIALS
ORGANS
OXIDOREDUCTASES
RADIATION EFFECTS
RADIATION INJURIES
RADIATIONS
RADIOASSAY
RADIOIMMUNODETECTION
RADIOIMMUNOLOGY
RODENTS
SEPARATION PROCESSES
SKIN DISEASES
TRACER TECHNIQUES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques