Design of a sup 13 C (1H) RF probe for monitoring the in vivo metabolism of (1- sup 13 C)glucose in primate brain

Journal Article · Mon Jan 01 00:00:00 EST 1990 · Magnetic Resonance in Medicine; (USA)

DOI:https://doi.org/10.1002/mrm.1910130102· OSTI ID:6896639

Hammer, B E; Sacks, W; Bigler, R E; Hennessy, M J; Sacks, S; Fleischer, A; Zanzonico, P B ^[1]

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1. Intermagnetics General Corporation, Guilderland, NY (USA)

The design of an RF probe suitable for obtaining proton-decoupled {sup 13}C spectra from a subhuman primate brain is described. Two orthogonal saddle coils, one tuned to the resonant frequency of {sup 13}C and the other to the resonant frequency of 1H, were used to monitor the in vivo metabolism of (1-{sup 13}C)glucose in rhesus monkey brain at 2.1 T. Difference spectra showed the appearance of {sup 13}C-enriched glutamate and glutamine 30 to 40 min after a bolus injection of (1-{sup 13}C)glucose.

• OSTI ID: 6896639
• Journal Information: Magnetic Resonance in Medicine; (USA), Vol. 13:1; ISSN 0740-3194
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
NMR IMAGING
GLUCOSE
METABOLISM
CARBON 13
GLUTAMIC ACID
GLUTAMINE
MONKEYS
NUCLEAR MAGNETIC RESONANCE
PROTONS
ALDEHYDES
AMIDES
AMINO ACIDS
ANIMALS
BARYONS
BODY
CARBOHYDRATES
CARBON ISOTOPES
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
DIAGNOSTIC TECHNIQUES
ELEMENTARY PARTICLES
EVEN-ODD NUCLEI
FERMIONS
HADRONS
HEXOSES
ISOTOPES
LIGHT NUCLEI
MAGNETIC RESONANCE
MAMMALS
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
NUCLEONS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PRIMATES
RESONANCE
SACCHARIDES
STABLE ISOTOPES
VERTEBRATES
550600* - Medicine