Atrial distension of isolated rabbit hearts and release of atrial natriuretic factor
Abstract
Interventions that increase atrial pressures in humans or laboratory animals release atrial natriuretic factor (ANF) into the circulation. The authors studied the relation between distension of the right or left atrium and release of ANF in retrograde-perfused isolated rabbit hearts. A fluid-filled balloon within the right or left atrium was inflated to a mean pressure of 5, 10, 15, or 20 mmHg, and ANF in the cardiac effluent was measured by radioimmunoassay. The slope of the regression line relating ANF release to atrial distending pressure was steeper for the left than right atrium, indicating that, at comparable increases in mean pressures, the left atrium releases more ANF than does the right atrium. Left atrial tissue concentration ANF was greater than right atrial. In contrast to previous studies showing right atrial dominance in rats, the left atria of isolated, perfused rabbit hearts contain more ANF and release more in response to atrial distension.
- Authors:
-
- Univ. of Colorado Health Sciences Center, Denver (USA) Clinical Research Institute of Montreal, Quebec (Canada)
- Publication Date:
- OSTI Identifier:
- 6896333
- Resource Type:
- Journal Article
- Journal Name:
- American Journal of Physiology; (USA)
- Additional Journal Information:
- Journal Volume: 255:2; Journal ID: ISSN 0002-9513
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE; BLOOD PRESSURE; DOSE-RESPONSE RELATIONSHIPS; PEPTIDE HORMONES; RADIOIMMUNOASSAY; HEART; LIQUID COLUMN CHROMATOGRAPHY; PERFUSED TISSUES; RABBITS; ANIMAL TISSUES; ANIMALS; BIOASSAY; BODY; CARDIOVASCULAR SYSTEM; CHROMATOGRAPHY; DIAGNOSTIC TECHNIQUES; HORMONES; IMMUNOASSAY; IMMUNOLOGY; ISOTOPE APPLICATIONS; MAMMALS; ORGANS; RADIOASSAY; RADIOIMMUNODETECTION; RADIOIMMUNOLOGY; SEPARATION PROCESSES; TISSUES; TRACER TECHNIQUES; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
Citation Formats
Synhorst, D P, and Gutkowska, J. Atrial distension of isolated rabbit hearts and release of atrial natriuretic factor. United States: N. p., 1988.
Web.
Synhorst, D P, & Gutkowska, J. Atrial distension of isolated rabbit hearts and release of atrial natriuretic factor. United States.
Synhorst, D P, and Gutkowska, J. 1988.
"Atrial distension of isolated rabbit hearts and release of atrial natriuretic factor". United States.
@article{osti_6896333,
title = {Atrial distension of isolated rabbit hearts and release of atrial natriuretic factor},
author = {Synhorst, D P and Gutkowska, J},
abstractNote = {Interventions that increase atrial pressures in humans or laboratory animals release atrial natriuretic factor (ANF) into the circulation. The authors studied the relation between distension of the right or left atrium and release of ANF in retrograde-perfused isolated rabbit hearts. A fluid-filled balloon within the right or left atrium was inflated to a mean pressure of 5, 10, 15, or 20 mmHg, and ANF in the cardiac effluent was measured by radioimmunoassay. The slope of the regression line relating ANF release to atrial distending pressure was steeper for the left than right atrium, indicating that, at comparable increases in mean pressures, the left atrium releases more ANF than does the right atrium. Left atrial tissue concentration ANF was greater than right atrial. In contrast to previous studies showing right atrial dominance in rats, the left atria of isolated, perfused rabbit hearts contain more ANF and release more in response to atrial distension.},
doi = {},
url = {https://www.osti.gov/biblio/6896333},
journal = {American Journal of Physiology; (USA)},
issn = {0002-9513},
number = ,
volume = 255:2,
place = {United States},
year = {Mon Aug 01 00:00:00 EDT 1988},
month = {Mon Aug 01 00:00:00 EDT 1988}
}