Nitrogen dioxide effects on progression of mouse lymphoma, a blood cell malignancy. Final report, 17 July 1986-16 April 1988
Earlier studies employing the injection of cancer cells into mice indicated that nitrogen dioxide facilitated the spread and establishment of cancer. The study was initiated to verify that finding, using an animal model that has more similarities to human cancer. The model used was a strain of mouse (AKR/cum) that develops a spontaneous blood-cell malignancy. The results of the study showed that the malignancy tended to develop later and spread less extensively while the percentage of specific T-lymphocytes was reduced in mice exposed to 0.25-ppm nitrogen dioxide when compared to mice held in clean air. Mortality due to cancer in the exposed mice was also reduced. The investigators noted that the result is consistent with exposure causing impairment of immune cells, the T-lymphocytes that participate in the malignancy. These results suggest that, at least in the strain of mouse studied, ambient levels of nitrogen dioxide may affect the immune system.
- Research Organization:
- University of Southern California, Los Angeles (USA). Dept. of Pathology
- OSTI ID:
- 6895441
- Report Number(s):
- PB-88-215660/XAB
- Resource Relation:
- Other Information: See also DE83-014964
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
54 ENVIRONMENTAL SCIENCES
AIR POLLUTION
BIOLOGICAL EFFECTS
BLOOD CELLS
LYMPHOMAS
NITROGEN DIOXIDE
IMMUNOLOGY
LABORATORY ANIMALS
PROGRESS REPORT
RATS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BODY FLUIDS
CHALCOGENIDES
DISEASES
DOCUMENT TYPES
IMMUNE SYSTEM DISEASES
MAMMALS
MATERIALS
NEOPLASMS
NITROGEN COMPOUNDS
NITROGEN OXIDES
OXIDES
OXYGEN COMPOUNDS
POLLUTION
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
550900 - Pathology
500200 - Environment
Atmospheric- Chemicals Monitoring & Transport- (-1989)