Technetium-99m antimony colloid for bone-marrow imaging
Technetium-99m antimony colloid was prepared in our laboratory for bone-marrow imaging. Optimal production of colloid particles of size range 1 to 13 nm was achieved by the use of polyvinylpyrrolidone of mol. wt. 44,000. Electron microscopy was used to size the particles. Studies in rabbits showed exclusive concentration in the subendothelial dendritic phagocytes of the bone marrow. Pseudopods from these cells were found to traverse interendothelial junctions and concentrate colloid from the sinusoids. Imaging studies of bone marrow in rabbits showed the superiority of the Tc-99m antimony colloid over the much larger colloidal particle of Tc-99m sulfur colloid. Tissue distribution studies in the rat confirmed that bone-marrow uptake of Tc-99m antimony colloid was greater than that of Tc-99m sulfur colloid, although blood clearance was much slower.
- Research Organization:
- Univ. of Western Australia, Nedlands
- OSTI ID:
- 6887443
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 21:11; Conference: 28. annual meeting of the Society of Nuclear Medicine, Las Vegas, NV, USA, 16 Jun 1981
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
59 BASIC BIOLOGICAL SCIENCES
ANTIMONY
RADIOPHARMACEUTICALS
BONE MARROW
SCINTISCANNING
CHEMICAL PREPARATION
TECHNETIUM 99
BLOOD CELLS
COMPARATIVE EVALUATIONS
ELECTRON MICROSCOPY
ISOMERIC NUCLEI
MOLECULAR WEIGHT
PARTICLE SIZE
RABBITS
RADIOCOLLOIDS
RATS
SULFUR
UPTAKE
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
COLLOIDS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISPERSIONS
DRUGS
ELEMENTS
HEMATOPOIETIC SYSTEM
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MATERIALS
METALS
MICROSCOPY
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RODENTS
SIZE
SYNTHESIS
TECHNETIUM ISOTOPES
TISSUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
400702 - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials
551001 - Physiological Systems- Tracer Techniques