Bolus injections of measured amounts of radioactivity

Journal Article · Tue Mar 01 00:00:00 EST 1988 · J. Nucl. Med. Technol.; (United States)

OSTI ID:6879158

Wesolowski, C A; Hogendoorn, P; Vandierendonck, R; Driedger, A A

Many time-based radionuclide techniques, such as glomerular filtration rate measurement (GFR), require prompt intravenous delivery of and accurately measured tracer bolus with minimal residual tracer retention at the injection site. The quality assurance aspects of two antecubital vein, quantitative injection techniques were investigated. A flush bolus technique using a tuberculin syringe piggybacked onto a 10-ml saline flush was compared to a single blood pressure cuff injection technique. Scintillation camera data for each technique were compared for bolus duration in the abdominal aorta and for residual activity at the injection site at 5 min. Bolus times were measured as the FWHM of the gamma variate fit to the abdominal aortic regional time-activity curves. Relatively little focal activity was seen in the antecubital injection site following the flush bolus: marked residual activity was seen following the blood pressure cuff injections. The injection site/arm background ratios averaged 1.3 for the flush bolus and 30.1 for the cuff technique. Although both methods allowed accurate in vitro determination of administered radioactivity, only the tuberculin syringe flush bolus technique was acceptable for time-based quantitation because of its superior in vivo characteristics.

• Research Organization: Univ. of Western Ontario, London (Canada)
• OSTI ID: 6879158
• Journal Information: J. Nucl. Med. Technol.; (United States), Vol. 16:1
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
KIDNEYS
DYNAMIC FUNCTION STUDIES
SCINTISCANNING
RADIOPHARMACEUTICALS
RENAL CLEARANCE
DIAGNOSTIC USES
GLOMERULI
PATIENTS
ULTRAFILTRATION
BODY
CLEARANCE
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DRUGS
EXCRETION
FILTRATION
LABELLED COMPOUNDS
ORGANS
RADIOISOTOPE SCANNING
SEPARATION PROCESSES
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics