Molecular cloning of the human homeobox gene goosecoid (GSC) and mapping of the gene to human chromosome 14q32. 1

Blum, M; De Robertis, E M; Geissert, D; Kojis, T; Heinzmann, C; Klisak, I; Sparkes, R S

doi:10.1006/geno.1994.1281

Title: Molecular cloning of the human homeobox gene goosecoid (GSC) and mapping of the gene to human chromosome 14q32. 1

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Abstract

Goosecoid is a homeobox gene first isolated from a Xenopus dorsal lip cDNA library. Homologous genes have been isolated from mouse, zebrafish, and chick. In all species examined, the gene is expressed and plays an important role during the process of gastrulation in early embryonic development. The authors report here the cloning of the human goosecoid (GSC) from a genomic library and the sequence of its encoded protein. The genomic organization and protein sequence of the human gene are highly conserved with respect to those of its Xenopus and mouse counterparts: all three genes consist of three exons, with conserved exon-intron boundaries. The sequence of the homeo-domain is 100% conserved in most vertebrates. Using somatic cell hybrid and chromosomal in situ hybridization, the gene was mapped to chromosome 14q32.1. 30 refs., 3 figs., 2 tabs.

Authors:

Blum, M; De Robertis, E M; Geissert, D ^[1]; Kojis, T; Heinzmann, C; Klisak, I; Sparkes, R S ^[2]

Univ. of California, Los Angeles, CA (United States)
Univ. of California School of Medicine, Los Angeles, CA (United States)

Publication Date:: Sun May 15 00:00:00 EDT 1994

OSTI Identifier:: 6872520

Resource Type:: Journal Article

Journal Name:: Genomics; (United States)

Additional Journal Information:: Journal Volume: 21:2; Journal ID: ISSN 0888-7543

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; HUMAN CHROMOSOME 14; GENETIC MAPPING; ONTOGENESIS; GENE REGULATION; AMINO ACID SEQUENCE; DNA SEQUENCING; DNA-CLONING; CHROMOSOMES; CLONING; DNA HYBRIDIZATION; HUMAN CHROMOSOMES; HYBRIDIZATION; MAPPING; MOLECULAR STRUCTURE; STRUCTURAL CHEMICAL ANALYSIS; 550400* - Genetics

Citation Formats


                    Blum, M, De Robertis, E M, Geissert, D, Kojis, T, Heinzmann, C, Klisak, I, and Sparkes, R S. Molecular cloning of the human homeobox gene goosecoid (GSC) and mapping of the gene to human chromosome 14q32. 1.  United States: N. p., 1994. 
        Web.  doi:10.1006/geno.1994.1281.

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                    Blum, M, De Robertis, E M, Geissert, D, Kojis, T, Heinzmann, C, Klisak, I, & Sparkes, R S. Molecular cloning of the human homeobox gene goosecoid (GSC) and mapping of the gene to human chromosome 14q32. 1.  United States.  https://doi.org/10.1006/geno.1994.1281

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                    Blum, M, De Robertis, E M, Geissert, D, Kojis, T, Heinzmann, C, Klisak, I, and Sparkes, R S. 1994.  
        "Molecular cloning of the human homeobox gene goosecoid (GSC) and mapping of the gene to human chromosome 14q32. 1".  United States.  https://doi.org/10.1006/geno.1994.1281.

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@article{osti_6872520,

  title        = {Molecular cloning of the human homeobox gene goosecoid (GSC) and mapping of the gene to human chromosome 14q32. 1},

  author       = {Blum, M and De Robertis, E M and Geissert, D and Kojis, T and Heinzmann, C and Klisak, I and Sparkes, R S},

  abstractNote = {Goosecoid is a homeobox gene first isolated from a Xenopus dorsal lip cDNA library. Homologous genes have been isolated from mouse, zebrafish, and chick. In all species examined, the gene is expressed and plays an important role during the process of gastrulation in early embryonic development. The authors report here the cloning of the human goosecoid (GSC) from a genomic library and the sequence of its encoded protein. The genomic organization and protein sequence of the human gene are highly conserved with respect to those of its Xenopus and mouse counterparts: all three genes consist of three exons, with conserved exon-intron boundaries. The sequence of the homeo-domain is 100% conserved in most vertebrates. Using somatic cell hybrid and chromosomal in situ hybridization, the gene was mapped to chromosome 14q32.1. 30 refs., 3 figs., 2 tabs.},

  doi          = {10.1006/geno.1994.1281},

  url          = {https://www.osti.gov/biblio/6872520},
  journal      = {Genomics; (United States)},

  issn         = {0888-7543},

  number       = ,

  volume       = 21:2,

  place        = {United States},

  year         = {Sun May 15 00:00:00 EDT 1994},

  month        = {Sun May 15 00:00:00 EDT 1994}

}

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https://doi.org/10.1006/geno.1994.1281

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