Tissue distribution of cadmium-109 after tracheal and gastric administration in rats

Journal Article · Fri Oct 01 00:00:00 EDT 1993 · Bulletin of Environmental Contamination and Toxicology; (United States)

DOI:https://doi.org/10.1007/BF00192182· OSTI ID:6871148

Doi, R; Chowdhury, P; Nishikawa, M; Rayford, P L ^[1]

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1. Univ. of Arkansas for Medical Sciences, Little Rock, AR (United States)

Cadmium is known to be a toxic trace element and its ingestion into the human body via dietary, inhalation, occupational, or non-occupational sources can induce a variety of pulmonary, renal, or reproductive dysfunction. Many acute and chronic studies with cadmium have been conducted in experimental animals to determine its mechanism of action, and it has been reported that cadmium may enhance or deactivate several enzyme systems in vitro or in vivo, and it may act as a potent calcium blocker, and can inhibit calmodulin activity. In addition, cadmium is distributed and retained in organ systems such as liver, kidney and lung. We have previously shown that a significant amount of cadmium is accumulated in lung, kidney, liver and gastrointestinal tract following intravenous or intraperitoneal injection. This study was conducted to delineate the tissue distribution of cadmium in animals following more physiologic route of exposure, such as tracheal and gastric administration of cadmium. 14 refs., 2 figs.

• OSTI ID: 6871148
• Journal Information: Bulletin of Environmental Contamination and Toxicology; (United States), Vol. 51:4; ISSN 0007-4861
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CADMIUM 109
BIOLOGICAL ACCUMULATION
BIOLOGICAL EFFECTS
TISSUE DISTRIBUTION
ANIMAL TISSUES
GASTROINTESTINAL TRACT
KIDNEYS
LIVER
LUNGS
BETA DECAY RADIOISOTOPES
BODY
CADMIUM ISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GLANDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
NUCLEI
ORGANS
RADIOISOTOPES
RESPIRATORY SYSTEM
TISSUES
YEARS LIVING RADIOISOTOPES
560300* - Chemicals Metabolism & Toxicology