Monitoring of aflatoxins and ochratoxin A in Czechoslovak human sera by immunoassay
- Institute of Chemical Technology, Prague (Czechoslovakia)
- Univ. of Agriculture, Prague (Czechoslovakia)
Since a level of food contamination with aflatoxins and ochratoxin A has been found low in Czechoslovakia, human exposure to these mycotoxins may not be negligible. However, analysis of food samples provides only indirect evidence of mycotoxin ingestion and no evidence about mycotoxin absorption. Direct evidence can only be obtained by analysis of human body fluids. Therefore, the authors decided to carry out a monitoring of aflatoxin and ochratoxin A level in human sera. In general, TLC and HPLC are most commonly used to analyze mycotoxins and its metabolites. The recent development of immunochemical techniques opens the possibility of determining individual exposure in a relatively large human population. These assays have the advantage of high specificity and sensitivity. Sample through-put is high, and the methods are technically simple and can be performed at low cost.
- OSTI ID:
- 6870067
- Journal Information:
- Bulletin of Environmental Contamination and Toxicology; (USA), Vol. 44:3; ISSN 0007-4861
- Country of Publication:
- United States
- Language:
- English
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TOXINS
RADIOIMMUNOASSAY
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LIGANDS
MAN
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AMINO ACIDS
ANIMALS
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CHROMATOGRAPHY
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EUROPE
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ISOTOPE APPLICATIONS
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RADIOIMMUNODETECTION
RADIOIMMUNOLOGY
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TOXIC MATERIALS
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VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics