Spatial heterogeneity of local blood flow and metabolite content in dog hearts
- Albert Einstein College of Medicine, New York, NY (USA)
Spatial variation (heterogeneity) of myocardial blood flow was studied under basal conditions in relation to four biochemical markers: creatine kinase (CK), lactate dehydrogenase (LDH), ATP, and glycogen. A total of 508 individual 0.5-g samples from the left ventricular free wall was studied in 12 dogs. Myocardial blood flow was measured by radioactive microspheres injected via a pigtail catheter into the left ventricle during light sedation; following thoracotomy, a second set of microspheres was injected via a catheter into the left atrium. In 27-54 samples/heart, myocardial blood flow, CK, LDH, protein, ATP, and glycogen were determined, permitting a direct correspondence between local blood flow and metabolic markers in each sample and an assessment of the spatial heterogeneity of flow and metabolite content. The coefficient of variation, which defines the extent of spatial heterogeneity, averaged 20% for closed-chest flow measurement, 19% for open-chest flow measurement, 22% for CK, 17% for LDH, 15% for protein, 8% for ATP, and 18% for glycogen. The correlation between local blood flow and the studied metabolities can only explain a minor portion of the spatial heterogeneity of myocardial blood flow. Although a physiological link between blood flow and metabolite content for small regions of the heart is demonstrated, the true local variability of blood flow may be modulated predominantly by other factors.
- OSTI ID:
- 6868076
- Journal Information:
- American Journal of Physiology; (USA), Vol. 254:2; ISSN 0002-9513
- Country of Publication:
- United States
- Language:
- English
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BLOOD FLOW
RADIOASSAY
LACTATE DEHYDROGENASE
BIOCHEMISTRY
MYOCARDIUM
METABOLISM
PHOSPHOTRANSFERASES
ATP
CHROMIUM 51
COBALT 57
DOGS
GLYCOGEN
HEART
MICROSPHERES
RUTHENIUM 103
TIN 113
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOHYDRATES
CARDIOVASCULAR SYSTEM
CHEMISTRY
CHROMIUM ISOTOPES
COBALT ISOTOPES
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
ENZYMES
EVEN-ODD NUCLEI
HEMIACETAL DEHYDROGENASES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
MUSCLES
NUCLEI
NUCLEOTIDES
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PHOSPHORUS-GROUP TRANSFERASES
POLYSACCHARIDES
RADIOISOTOPES
RUTHENIUM ISOTOPES
SACCHARIDES
TIN ISOTOPES
TRANSFERASES
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques