Tc-99m HMDP (Hydroxymethylene diphosphonate): a radiopharmaceutical for skeletal and acute myocardial infarct imaging. I. synthesis and distribution in animals. [Rats, dogs]

Conference · Wed Oct 01 00:00:00 EDT 1980 · J. Nucl. Med.; (United States)

OSTI ID:6861338

Bevan, J A; Tofe, A J; Benedict, J J; Francis, M D; Barnett, B L

Technetium-99m hydroxymethylene diphosphonate (Tc-99m HMDP) is a new diphosphonate skeletal imaging agent. Animal studies show that Tc-99m HMDP has a higher uptake on bone and a more rapid clearance from the blood than any of the three technetium-labeled bone imaging agents in current use: Tc-99m methylene diphosphonate (MDP), Tc-99m (1-hydroxyethylidene) diphosphonate (HEDP), and Tc-99m pyrophosphate (PPi). On the basis of these animal studies, Tc-99m HMDP is a highly promising candidate for skeletal imaging.

• Research Organization: Procter and Gamble Co., Cincinnati, OH
• OSTI ID: 6861338
• Journal Information: J. Nucl. Med.; (United States), Vol. 21:10; Conference: 28. annual meeting of the Society of Nuclear Medicine, Las Vegas, NV, USA, 16 Jun 1981
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
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BLOOD-PLASMA CLEARANCE
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SYNTHESIS
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