Water and exchangeable sodium in Goldblatt two-kidney, two-clip hypertensive rats
Exchangeable /sup 22/Na (ExNa), total body water (TBW) and the inulin space (InSp) were determined in two-kidney, two-clip (2K-2C) hypertensive and sham operated (normotensive) control rats 6-8 weeks after surgery. TBW (ml/kg lean body weight) was the same in hypertensive and sham rats. In contrast, ExNa (mEq/kglbw) and InSp (ml/kglbw) significantly increased (p less than 0.01) in rats whose hypertension did not exceed 170 mmHg. Consequently, sham, moderate hypertensive (less than 170 mmHg) and severe hypertensive (less than 170 mmHg) animals showed equal TBW but differed in body water distribution in that moderately hypertensive animals displayed a redistribution of water in favor of the extracellular space.
- Research Organization:
- Universidad de Buenos Aires, Argentina
- OSTI ID:
- 6859370
- Journal Information:
- Clin. Exp. Hypertens., Part A; (United States), Vol. 8
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
HYPERTENSION
PATHOGENESIS
WATER
TISSUE DISTRIBUTION
ADIPOSE TISSUE
BODY FLUIDS
EXTRACELLULAR SPACE
KIDNEYS
RATS
SODIUM 22
TRACER TECHNIQUES
ALKALI METAL ISOTOPES
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY
CARDIOVASCULAR DISEASES
CONNECTIVE TISSUE
DISEASES
DISTRIBUTION
HYDROGEN COMPOUNDS
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAMMALS
MATERIALS
NUCLEI
ODD-ODD NUCLEI
ORGANS
OXYGEN COMPOUNDS
RADIOISOTOPES
RODENTS
SODIUM ISOTOPES
SPACE
SYMPTOMS
TISSUES
VASCULAR DISEASES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550901* - Pathology- Tracer Techniques