Renal damage in the mouse: the response to very small doses per fraction
Experiments were undertaken to study the effect on the mouse kidney of repeated X-ray doses in the range 0.2 to 1.6 Gy per fraction and neutron doses in the range 0.05 to 0.25 Gy per fraction. A top-up design of experiment was used, so that additional graded doses of d(4)-Be neutrons (EN = 2.3 MeV) were given to bring the subthreshold damage produced by these treatments into the measurable range. This approach avoided the necessity to use a large number of fractions to study low doses per fraction. Renal damage was assessed using three methods: 51Cr-EDTA clearance, urine output, and hematocrit at 16-50 weeks postirradiation. The dose-response curves obtained were resolved best at 29 weeks. However, the results were also examined by fitting second-order polynomials to the data for response versus time postirradiation and using interpolated values from these functions at 29 weeks to construct dose-response curves. This method reduced slightly the variation in the dose-response data, but the interrelationship between the dose-response curves remained the same. The data were used to test the linear-quadratic (LQ) description of the underlying X-ray dose-fractionation relationship. The model fits well down to X-ray doses per fraction of approximately 1 Gy, but lower X-ray doses were more effective per gray than predicted by LQ, as seen previously in skin. This increased X-ray effectiveness and deviation from LQ are reflected directly in a decrease in the RBE of d(4)-Be neutrons relative to X-rays at low doses, since the underlying response to these neutrons is linear in this low-dose region.
- Research Organization:
- Mount Vernon Hospital, Northwood, Middlesex (England)
- OSTI ID:
- 6856277
- Journal Information:
- Radiat. Res.; (United States), Vol. 114:2
- Country of Publication:
- United States
- Language:
- English
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KIDNEYS
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NEUTRONS
RBE
X RADIATION
CHROMIUM 51
CLEARANCE
COMPARATIVE EVALUATIONS
DOSE-RESPONSE RELATIONSHIPS
EDTA
FRACTIONATED IRRADIATION
MICE
RADIATION DOSES
AMINO ACIDS
ANIMALS
BARYONS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
CHROMIUM ISOTOPES
DOSES
ELECTROMAGNETIC RADIATION
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTARY PARTICLES
EVEN-ODD NUCLEI
FERMIONS
HADRONS
INTERMEDIATE MASS NUCLEI
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
MAMMALS
NUCLEI
NUCLEONS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals