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Title: Chemical breakdown of radioaerosols during nebulization

Abstract

The diagnostic utility of radioaerosols for lung ventilation and lung permeability procedures requires a strong, stable coordinate covalent bond between a radionuclide and a ligand. The stability of the radiopharmaceutical before and after nebulization and hence its molecular size, are an absolute prerequisite for the method to be reproducible. To examine the possible effects of aerosolization on radiopharmaceuticals used for pulmonary imaging, the authors examined the radiochemical purity of Tc-99m DTPA following ultrasonic nebulization, jet nebulization (Dautrebande D-31), and inhalation with subsequent appearance in plasma and urine of dogs. Paper and liquid chromatographic methods were applied to determine radiochemical purity. Chromatographic assays showed a binding efficiency of less than 50% for ultrasonicly aerosolized Tc-99m DTPA. Cooling of the ultrasonic coupling fluid increased the binding efficiency to greater than 95% following nebulization and inhalation. Jet nebulization did not affect the radiochemical purity of the radiopharmaceutical. Ultrasonic nebulization will partially destroy the Tc-99m DTPA complex; cooling the ultrasonic connecting fluid and constant aerosol monitoring are required for consistent, reproducible results.

Authors:
; ; ; ; ; ;
Publication Date:
Research Org.:
Univ. of Rochester School of Medicine and Dentistry, Rochester, NY
OSTI Identifier:
6854854
Report Number(s):
CONF-850611-
Journal ID: CODEN: JNMEA; TRN: 87-010764
Resource Type:
Conference
Journal Name:
J. Nucl. Med.; (United States)
Additional Journal Information:
Journal Volume: 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; LUNGS; PERMEABILITY; RADIOISOTOPE SCANNING; ULTRASONOGRAPHY; TECHNETIUM 99; DIAGNOSTIC USES; BINDING ENERGY; BLOOD PLASMA; CHEMICAL BONDS; CHROMATOGRAPHY; COMPARATIVE EVALUATIONS; DIAGNOSIS; DOGS; INHALATION; LIGANDS; MONITORING; PURIFICATION; RADIOACTIVE AEROSOLS; RADIOCHEMISTRY; RADIOPHARMACEUTICALS; STABILITY; URINE; VENTILATION; AEROSOLS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BLOOD; BODY; BODY FLUIDS; CHEMISTRY; COLLOIDS; COUNTING TECHNIQUES; DISPERSIONS; DRUGS; ENERGY; HOURS LIVING RADIOISOTOPES; INTAKE; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPES; RESPIRATORY SYSTEM; SEPARATION PROCESSES; SOLS; TECHNETIUM ISOTOPES; USES; VERTEBRATES; WASTES; YEARS LIVING RADIOISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 550602 - Medicine- External Radiation in Diagnostics- (1980-)

Citation Formats

Waldman, D L, Weber, D A, Oberdrster, G, Drago, S R, Utell, M S, Hyde, R W, and Morrow, P E. Chemical breakdown of radioaerosols during nebulization. United States: N. p., 1985. Web.
Waldman, D L, Weber, D A, Oberdrster, G, Drago, S R, Utell, M S, Hyde, R W, & Morrow, P E. Chemical breakdown of radioaerosols during nebulization. United States.
Waldman, D L, Weber, D A, Oberdrster, G, Drago, S R, Utell, M S, Hyde, R W, and Morrow, P E. 1985. "Chemical breakdown of radioaerosols during nebulization". United States.
@article{osti_6854854,
title = {Chemical breakdown of radioaerosols during nebulization},
author = {Waldman, D L and Weber, D A and Oberdrster, G and Drago, S R and Utell, M S and Hyde, R W and Morrow, P E},
abstractNote = {The diagnostic utility of radioaerosols for lung ventilation and lung permeability procedures requires a strong, stable coordinate covalent bond between a radionuclide and a ligand. The stability of the radiopharmaceutical before and after nebulization and hence its molecular size, are an absolute prerequisite for the method to be reproducible. To examine the possible effects of aerosolization on radiopharmaceuticals used for pulmonary imaging, the authors examined the radiochemical purity of Tc-99m DTPA following ultrasonic nebulization, jet nebulization (Dautrebande D-31), and inhalation with subsequent appearance in plasma and urine of dogs. Paper and liquid chromatographic methods were applied to determine radiochemical purity. Chromatographic assays showed a binding efficiency of less than 50% for ultrasonicly aerosolized Tc-99m DTPA. Cooling of the ultrasonic coupling fluid increased the binding efficiency to greater than 95% following nebulization and inhalation. Jet nebulization did not affect the radiochemical purity of the radiopharmaceutical. Ultrasonic nebulization will partially destroy the Tc-99m DTPA complex; cooling the ultrasonic connecting fluid and constant aerosol monitoring are required for consistent, reproducible results.},
doi = {},
url = {https://www.osti.gov/biblio/6854854}, journal = {J. Nucl. Med.; (United States)},
number = ,
volume = 26:5,
place = {United States},
year = {Wed May 01 00:00:00 EDT 1985},
month = {Wed May 01 00:00:00 EDT 1985}
}

Conference:
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