Limited myocardial perfusion reserve in patients with left ventricular hypertrophy

Journal Article · Thu Mar 01 00:00:00 EST 1990 · Journal of Nuclear Medicine; (USA)

OSTI ID:6854814

Goldstein, R A; Haynie, M ^[1]

---

1. Univ. of Texas Health Science Center, Houston (USA)

Experimental studies in animals have suggested that coronary flow reserve may be limited in patients with left ventricular hypertrophy (LVH). Accordingly, to noninvasively determine the effect of LVH on myocardial perfusion reserve, 25 patients, 9 with LVH and 16 controls, underwent positron imaging with rubidium-82 (82Rb) (30-55 mCi) or nitrogen-13 (13N) ammonia (12-19 mCi) at rest and following intravenous dipyridamole and handgrip stress. LVH was documented by echocardiographic and/or electrocardiographic measurements. LVH patients had either no chest pain (n = 8) and/or a normal coronary angiogram (n = 6). Nine simultaneous transaxial images were acquired, and the mean ratio of stress to rest activity (S:R), based on all regions for each heart, was calculated as an estimate of myocardial perfusion reserve. There were no regional differences in activity (i.e., perfusion defects) in any of the studies. S:R averaged 1.41 +/- 0.10 (s.d.) for controls and 1.06 +/- 0.09 for patients with LVH (p less than 0.0001). These data provide support for an abnormality in perfusion reserve in patients with LVH.

• OSTI ID: 6854814
• Journal Information: Journal of Nuclear Medicine; (USA), Vol. 31:3; ISSN 0161-5505
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CARDIOVASCULAR DISEASES
DIAGNOSIS
CORONARIES
BLOOD FLOW
HEART
POSITRON COMPUTED TOMOGRAPHY
ELECTROCARDIOGRAMS
EXERCISE
NITROGEN 13
PATIENTS
PERFUSED ORGANS
RUBIDIUM 82
VASODILATORS
ALKALI METAL ISOTOPES
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
CARDIOVASCULAR AGENTS
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DIAGRAMS
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOTOPES
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
NITROGEN ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIOISOTOPES
RUBIDIUM ISOTOPES
TOMOGRAPHY
550601* - Medicine- Unsealed Radionuclides in Diagnostics