Reversal of lower esophageal sphincter hypotension and esophageal aperistalsis after treatment for hypothyroidism
A 65-year-old woman suffered from both chronic gastroesophageal reflux, which was complicated by columnar metaplasia (Barrett's epithelium), and profound hypothyroidism. An esophageal motility tracing showed absence of peristalsis in the lower esophagus and the lower esophageal sphincter (LES) could not be identified. Thyroid replacement therapy, in conjunction with antacid and cimetidine treatment, was associated not only with improvement in the gastroesophageal reflux symptoms, but also with a return of esophageal peristalsis and LES pressure to normal. To support our clinical observations, we rendered four cats hypothyroid with /sup 131/I and documented a fall in LES pressure. We propose that abnormal smooth-muscle function of the esophagus may be another manifestation of the gastrointestinal motility disturbances which are associated with hypothyroidism.
- Research Organization:
- Department of Medicine and Surgery, University of Massachusetts Medical School, Worcester, Massachusetts
- OSTI ID:
- 6852537
- Journal Information:
- J. Clin. Gastroenterol.; (United States), Vol. 4:4
- Country of Publication:
- United States
- Language:
- English
Similar Records
Esophageal blood flow in the cat. Normal distribution and effects of acid perfusion
Chronic xerostomia increases esophageal acid exposure and is associated with esophageal injury
Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
HYPOTHYROIDISM
SYMPTOMS
DIGESTIVE SYSTEM DISEASES
ESOPHAGUS
MUSCLES
THERAPY
PATIENTS
CATS
IODINE 131
RADIOINDUCTION
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISEASES
ENDOCRINE DISEASES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
VERTEBRATES
560162* - Radionuclide Effects
Kinetics
& Toxicology- Animals
Plants
Microorganisms
& Cells
550600 - Medicine