Cardiac function and rejection following transplantation of the heart

Conference · Wed May 01 00:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:6851859

Schober, O; Schuler, S; Gratz, K; Warnecke, H; Lang, W; Hetzer, R; Creutzig, H

It was the purpose of the study to evaluate the noninvasive detection of rejection following cardiac transplantation. Multigated cardiac blood pool imaging (MUGA) at rest with assessment of ejection fraction (EF) and regional wall motion was determined prospectively in 14 patients with 180 studies (follow up 5.1 +- 3.2 months) following orthotopic cardiac transplantation. The results were compared with histological examination of a percutaneous endocardial biopsy specimen (EMB) from the right ventricle. Diagnosis of rejection by EF measurement was defined by a decrease of 10% if EF < 70%, and 15% if EF > 70%. In 152 studies a normal MUGA study correlated with none rejection as defined by EMB. In 14 of 22 studies with moderate or severe rejection decrease of EF followed the rejection with a delay of 5 days. Septal wall motion abnormalities were typical. In 6 studies an abnormal temporal course of EF was not related to a similar finding in EMB. A sensitivity of 69% and a specifity of 96% can be estimated in the investigated group, in which all patients survived during the period of the study. It is concluded that rejection can be excluded by noninvasive MUGA (specifity 96%) and that MUGA is predictive of rejection (sensitivity 67%) mostly with a delay of 5 days.

• Research Organization: Dept. Nucl. Med. and Dept. Thoracic Surgery, Medical School, Hannover
• OSTI ID: 6851859
• Report Number(s): CONF-850611-
• Journal Information: J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
HEART
DYNAMIC FUNCTION STUDIES
GRAFT-HOST REACTION
TRANSPLANTS
MONITORING
BIOPSY
CARDIOGRAPHY
COMPARATIVE EVALUATIONS
CORRELATIONS
DIAGNOSIS
EVALUATION
HISTOLOGY
LABELLED POOL TECHNIQUES
PATIENTS
PHYSIOLOGY
BODY
CARDIOVASCULAR SYSTEM
DIAGNOSTIC TECHNIQUES
ISOTOPE APPLICATIONS
ORGANS
TRACER TECHNIQUES
551000* - Physiological Systems