A new gene encoding the ligand for deletion of T cells bearing Tcrb-V6 and V8.1 (Mtv-50)
- Nagoya Univ. School of Medicine (Japan)
- Kasetsart Univ., Nakhonpathom (Thailand)
The minor lymphocyte-stimulating antigen (Mls), which is defined by the demonstration of a strong primary T-cell proliferative response in a mixed lymphocyte culture between major histocompatibility complex-identical strains, is a representative of self superantigens (Sags) which bind to certain Tcrb-V elements, and delete T cells bearing these elements. Mls-1 antigen encoded by Mtv-7 stimulates T cells bearing Tcrb-V6, V7, V8.1, or V9 in vitro, and delete these T cells in vivo. Recently, Mtv-43, Mtv-44, and exogenous MMTV (SW) have also been found to encode Mls-1-like antigens, which delete Tcrb-V6, V7 (except Mtv-44), V8.1- and/or V9-bearing T cells. In sharp contrast to Mls-1, Mls-1-like antigens encoded by Mtv-43 and MMTV(SW) show only a limited in vitro stimulatory capacity. 9 refs., 1 fig.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 68501
- Journal Information:
- Immunogenetics, Vol. 40, Issue 4; Other Information: PBD: 1994
- Country of Publication:
- United States
- Language:
- English
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