EORTC treatment of early stages of Hodgkin's disease: The role of radiotherapy
- Institut Gustave-Roussy, Villejuif, France
Since 1964, the European Organisation for Research and Treatment of Cancer has conducted three subsequent clinical trials on clinical Stages(CS) I+II Hodgkin's disease (HD) in which 1059 patients have been entered. The first trial compared regional radiotherapy (RT) with mantle field or inverted Y, versus the same RT followed by a weekly injection of vinblastine for 2 years. The relapse free survival (RFS) and overall survival (S) were higher in patients treated by RT and chemotherapy (CT). The second trial compared the therapeutic efficacy of splenic irradiation versus splenectomy and found that in both arms, RFS and S were identical. In the third trial, staging laparotomy was performed only to further delineate a good prognostic group which could be treated by RT alone. In this limited treatment group, there was no difference in RFS and S between mantle field and mantle field + para-aortic RT. In the extensive treatment group, total nodal irradiation (TNI) was compared with RT + MOPP. The RFS was slightly lower in the TNI arm, but there was no significant difference in S. The data of the 3 trials underline the importance of prognostic factors in the choice of optimal treatment and show that their significance depends upon the type of treatment. Multivariate statistical analyses showed that the main prognostic factors, which can help to identify the subsets of patients who can be treated by RT alone, are (1) systemic symptoms and elevated erythrocyte sedimentation rate (ESR), (2) the number of involved lymphatic areas, and (3) staging laparotomy.
- OSTI ID:
- 6849120
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 10:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CHEMOTHERAPY
EVALUATION
RADIOTHERAPY
SURVIVAL TIME
MULTIVARIATE ANALYSIS
EUROPE
EXPERIMENTAL DATA
HODGKINS DISEASE
PARTIAL BODY IRRADIATION
PATIENTS
DATA
DISEASES
EXTERNAL IRRADIATION
INFORMATION
IRRADIATION
LYMPHOMAS
MATHEMATICS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUMERICAL DATA
RADIOLOGY
STATISTICS
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)