Relative permeability of retina and retinal pigment epithelium to the diffusion of tritiated water from vitreous to choroid

Journal Article · Sat Nov 01 00:00:00 EST 1986 · Arch. Ophthalmol. (Chicago); (United States)

DOI:https://doi.org/10.1001/archopht.1986.01050230116044· OSTI ID:6847689

Orr, G; Goodnight, R; Lean, J S

The movement of intravitreally injected tritiated water from the vitreous to the choroid was accelerated by the removal of intervening retina. Both rate of transfer and peak choroidal levels of the tracer were increased, but the proportion of the intravitreal dose recovered was unaltered. In contrast, the movement of tritiated water after diffuse damage to the retinal pigment epithelium by sodium iodate was similar to that of control eyes. The main resistance to the diffusion of this tracer from the vitreous to the choroid is the retina. The differential permeability of the retina and the retinal pigment epithelium may have a role in normal retinal adhesion.

• Research Organization: Univ. of Southern California, Los Angeles
• OSTI ID: 6847689
• Journal Information: Arch. Ophthalmol. (Chicago); (United States), Vol. 11
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
RETINA
PERMEABILITY
TRITIUM OXIDES
DIFFUSION
ADHESION
BODY FLUIDS
EYES
RABBITS
UVEA
ANIMALS
BIOLOGICAL MATERIALS
BODY
BODY AREAS
CHALCOGENIDES
FACE
HEAD
LABELLED COMPOUNDS
MAMMALS
MATERIALS
ORGANS
OXIDES
OXYGEN COMPOUNDS
SENSE ORGANS
TRITIUM COMPOUNDS
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques