The possible role of anemia in bone marrow uptake of radiocolloid

Conference · Sun Jan 01 00:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6844937

Skarzynski, J J; Spencer, R P; Karlmeddini, M K

Entry of Tc-99m-sulfur colloid into bone marrow is a frequent observation and possible causes have been discussed in the literature. Using a present formulation of the radiocolloid (Medi+Physics), the authors sought to define the distribution patterns of bone marrow uptake, and relate these back to the primary diagnosis. Three hundred consecutive cases (with spleen present) were analyzed. Only 18% of the patients were under age 29 years and 62% were age 50 or older. Posterior images were evaluated so that liver, spleen and bone marrow could be compared visually. Twelve % of the studies were within normal limits. In 33% of the patients, the liver or spleen showed a defect without a radiocolloid shift. In 41% of the cases, there was a shift of radioactivity to the spleen (spleen/liver greater than 1), but not to the bone marrow. In 12% of the patients, there was both a radiocolloid shift to the spleen and visible uptake in the bone marrow. Least common was uptake of radiocolloid in the vertebral bone marrow without a splenic radiocolloid shift: this occurred in only 5 cases (under 2% of the total). Looked at another way the authors can normalize the cases with radiocolloid shift to the spleen (but not elsewhere) to 100%. Then radiocolloid shift to both spleen and bone marrow occurred only 29% as frequently. Radicolloid in the bone marrow, but not shifted to the spleen, was unusual (5% as frequent). These 5 patients were analyzed; all had anemia. The Hb ranged from 7.9 - 10.6 gm/dl, and hematocrits from 23 - 30. Several etiologies were involved. Anemia may be a stimulus to bone marrow uptake of radiocolloid without major splenic accumulation.

• Research Organization: Dept. Nuclear Medicine, Univ. Connecticut Health Center, Farmington, CT
• OSTI ID: 6844937
• Report Number(s): CONF-840619-; TRN: 87-008761
• Journal Information: J. Nucl. Med.; (United States), Vol. 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ANEMIAS
DIAGNOSIS
BONE MARROW
RADIONUCLIDE KINETICS
TECHNETIUM 99
DIAGNOSTIC USES
UPTAKE
AGE DEPENDENCE
COLLOIDS
IMAGES
LIVER
PATIENTS
SPLEEN
SULFUR
TRACER TECHNIQUES
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DIGESTIVE SYSTEM
DISEASES
DISPERSIONS
ELEMENTS
GLANDS
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
SYMPTOMS
TECHNETIUM ISOTOPES
TISSUES
USES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics