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Title: Comparison of immunoreactive serum trypsinogen and lipase in Cystic Fibrosis

Abstract

The incidence of Cystic Fibrosis (CF) is 1 in 2,000. Early detection and treatment of CF may necessitate newborn screening with a reliable and cost-effective test. Serum immunoreactive trypsinogen (IRT) an enzyme produced by the pancreas, is detectable by radioimmunoassay (RIA) techniques. Recently, it has been shown that IRT is elevated in CF infants for the first few months of life and levels become subnormal as pancreatic insufficiency progresses. Other enzymes produced by the pancreas, such as lipase, are also elevated during this time. The author's earlier work confirmed previous reports of elevated IRT levels in CF infants. The development of a new RIA for lipase (nuclipase) has enabled comparison of these 2 pancreatic enzymes in C.F. Serum IRT and lipase determinations were performed on 2 groups of CF patients; infants under 1 year of age, and children between 1 and 18 years of age. Control populations of the same age groups were included. The results showed that both trypsin (161 +- 92 ng/ml, range 20 to 400) and lipase (167 +- 151 ng/ml, range 29 to 500) are elevated in CF in the majority of infants. Control infants had values of IRT ranging from 20 to 29.5 ng/ml andmore » lipase values ranging from 23 to 34 ng/ml. IRT becomes subnormal in most CF patients by 8 years of age as pancreatic function insufficiency increases. Lipase levels and IRT levels correlate well in infancy, but IRT is a more sensitive indicator of pancreatic insufficiency in older patients with CF.« less

Authors:
; ; ; ;
Publication Date:
Research Org.:
The Children's Memorial Hospital, Chicago, IL
OSTI Identifier:
6844366
Report Number(s):
CONF-840619-
Journal ID: CODEN: JNMEA; TRN: 87-008855
Resource Type:
Conference
Journal Name:
J. Nucl. Med.; (United States)
Additional Journal Information:
Journal Volume: 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; DIGESTIVE SYSTEM DISEASES; DIAGNOSIS; HEREDITARY DISEASES; INFANTS; LIPASE; RADIOIMMUNOASSAY; NEONATES; SCREENING; TRYPSIN; COST; IMMUNE SERUMS; PANCREAS; RELIABILITY; AGE GROUPS; BODY; CARBOXYLESTERASES; CHILDREN; DIGESTIVE SYSTEM; DISEASES; ENDOCRINE GLANDS; ENZYMES; ESTERASES; GLANDS; HYDROLASES; IMMUNOASSAY; IMMUNOLOGY; ISOTOPE APPLICATIONS; ORGANS; PEPTIDE HYDROLASES; RADIOASSAY; RADIOIMMUNOLOGY; SERINE PROTEINASES; TRACER TECHNIQUES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Lloyd-Still, J D, Weiss, S, Wessel, H, Fong, L, and Conway, J J. Comparison of immunoreactive serum trypsinogen and lipase in Cystic Fibrosis. United States: N. p., 1984. Web.
Lloyd-Still, J D, Weiss, S, Wessel, H, Fong, L, & Conway, J J. Comparison of immunoreactive serum trypsinogen and lipase in Cystic Fibrosis. United States.
Lloyd-Still, J D, Weiss, S, Wessel, H, Fong, L, and Conway, J J. 1984. "Comparison of immunoreactive serum trypsinogen and lipase in Cystic Fibrosis". United States.
@article{osti_6844366,
title = {Comparison of immunoreactive serum trypsinogen and lipase in Cystic Fibrosis},
author = {Lloyd-Still, J D and Weiss, S and Wessel, H and Fong, L and Conway, J J},
abstractNote = {The incidence of Cystic Fibrosis (CF) is 1 in 2,000. Early detection and treatment of CF may necessitate newborn screening with a reliable and cost-effective test. Serum immunoreactive trypsinogen (IRT) an enzyme produced by the pancreas, is detectable by radioimmunoassay (RIA) techniques. Recently, it has been shown that IRT is elevated in CF infants for the first few months of life and levels become subnormal as pancreatic insufficiency progresses. Other enzymes produced by the pancreas, such as lipase, are also elevated during this time. The author's earlier work confirmed previous reports of elevated IRT levels in CF infants. The development of a new RIA for lipase (nuclipase) has enabled comparison of these 2 pancreatic enzymes in C.F. Serum IRT and lipase determinations were performed on 2 groups of CF patients; infants under 1 year of age, and children between 1 and 18 years of age. Control populations of the same age groups were included. The results showed that both trypsin (161 +- 92 ng/ml, range 20 to 400) and lipase (167 +- 151 ng/ml, range 29 to 500) are elevated in CF in the majority of infants. Control infants had values of IRT ranging from 20 to 29.5 ng/ml and lipase values ranging from 23 to 34 ng/ml. IRT becomes subnormal in most CF patients by 8 years of age as pancreatic function insufficiency increases. Lipase levels and IRT levels correlate well in infancy, but IRT is a more sensitive indicator of pancreatic insufficiency in older patients with CF.},
doi = {},
url = {https://www.osti.gov/biblio/6844366}, journal = {J. Nucl. Med.; (United States)},
number = ,
volume = 25:5,
place = {United States},
year = {Sun Jan 01 00:00:00 EST 1984},
month = {Sun Jan 01 00:00:00 EST 1984}
}

Conference:
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