Radiation response of the canine cardiovascular system

Journal Article · Tue Jun 01 00:00:00 EDT 1982 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575726· OSTI ID:6841991

Gavin, P R ^[1]; Gillette, E L

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1. Washington State Univ., Pullman

The hearts of dogs were irradiated with /sup 60/Co ..gamma.. rays. The dose required to produce pericardial effusion in 50% of the dogs by 180 days (PED/sub 50///sub 180/) was 1220 rad. For cardiac tamponade, the CTD /sub 50///sub 180/ was 1500 rad. Morphometric analyses of the hearts showed decreased capillary volume and increased fibrosis as radiation dose increased. The pericardial thickness increased with increased radiation dose. The slopes of the dose response for these parameters were similar as determined by linear regression of the parameter versus radiation dose.

• OSTI ID: 6841991
• Journal Information: Radiat. Res.; (United States), Vol. 90:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
HEART
BIOLOGICAL RADIATION EFFECTS
COBALT 60
DOGS
DOSE-RESPONSE RELATIONSHIPS
FIBROSIS
MORPHOLOGICAL CHANGES
RADIATION DOSES
RADIOSENSITIVITY
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CARDIOVASCULAR SYSTEM
COBALT ISOTOPES
DOSES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIOISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals