Survival of primates following orthotopic cardiac transplantation treated with total lymphoid irradiation and chemical immune suppression

Journal Article · Tue Dec 01 00:00:00 EST 1981 · Transplantation; (United States)

DOI:https://doi.org/10.1097/00007890-198112000-00003· OSTI ID:6841892

Pennock, J L; Reitz, B A; Bieber, C P; Aziz, S; Oyer, P E; Strober, S; Hoppe, R; Kaplan, H S; Stinson, E B; Shumway, N E

Fractionated total lymphoid irradiation (TLI) has been used for attempts at induction of a donor-specific tolerant-like state in allograft recipients and for immunosuppressive effects. Cyclosporin A (Cy A) has been shown to suppress rejection of organ grafts in many species including man. The present study was designed to test the effectiveness of TLI in combination with either CY A or rabbit anticynomolgus thymocyte globulin (ATG) and azathioprine. Thirty-one orthotopic cardiac allografts were performed using surface cooling and total circulatory arrest in outbred cynomolgus monkeys. TLI was administered preoperatively in fractions of 100 rad until a total of 600 or 1800 rad was achieved. Cy A was administered 17 mg/kg/day. All treatment groups demonstrated extended survival. Myocardial biopsies as early as 4 weeks were consistent with mild rejection in all treatment groups. No significant synergistic effect upon survival could be demonstrated utilizing TLI plus Cy A when compared with using Cy A alone. TLI (1800 rad) plus ATG and azathioprine was associated with a high incidence of early death attributable to leukopenia and infection. Cy A alone or in combination with TLI was associated with the development of lymphoid malignancy.

• Research Organization: Department of Cardiovascular Surgery, Stanford University School of Medicine, CA
• OSTI ID: 6841892
• Journal Information: Transplantation; (United States), Vol. 32:6
• Country of Publication: United States
• Language: English

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