Sensitivity to. gamma. rays of avian sarcoma and murine leukemia viruses. [/sup 60/Co, uv]

Journal Article · Mon Sep 01 00:00:00 EDT 1980 · Virology; (United States)

DOI:https://doi.org/10.1016/0042-6822(80)90051-3· OSTI ID:6839330

Toyoshima, K ^[1]; Niwa, O; Yutsudo, M; Sugiyama, H; Tahara, S; Sugahara, T

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1. Osaka Univ., Japan

The direct inactivation of avian and murine oncoviruses by ..gamma.. rays was examined using /sup 60/Co as a ..gamma..-ray source. The inactivation of murine leukemia virus (M-MuLV) followed single-hit kinetics while the subgroup D Schmidt-Ruppin strain of avian sarcoma virus (SR-RSV D) showed multihit inactivation kinetics with an extrapolation number of 5. The two viruses showed similar uv-inactivation kinetics. The genomic RNA of the SR-RSV D strain was degraded by ..gamma.. irradiation faster than its infectivity, but viral clones isolated from the foci formed after ..gamma.. irradiation had a complete genome. These results suggest that SR-RSV D has a strong repair function, possibly connected with reverse transcriptase activity.

• OSTI ID: 6839330
• Journal Information: Virology; (United States), Vol. 105:2
• Country of Publication: United States
• Language: English

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DOSE-RESPONSE RELATIONSHIPS
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EARLY RADIATION EFFECTS
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INTERMEDIATE MASS NUCLEI
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